Testing Negative – Staying Positive: Dr. Mikovits Santa Rosa XMRV Presentation by Paula Carnes

January 20, 2011

Posted by Cort Johnson

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4816-XMRVnodules.gif(Thanks to Paula for allowing us to post her review of Dr. Mikovits Talk here. You can find the original post at her blog here. )

I made the long trek from Las Vegas to Santa Rosa hoping to find answers to mysterious questions such as “What is the origin of XMRV?” or “Why would a retrovirus spread like an epidemic at Incline Village in a high school?” Do I have more answers now? I do know I made a wise choice to drive from Vegas. My trip was more fun than Dr. Mikovits’. She was stuck on a plane in Reno for several hours.On the way up I marveled at the mysterious fog covering California.

On the way back I wondered at Santa Cruz seeming to be a ghost town with virtually every beachfront restaurant not open for breakfast.

There’s a lot I don’t understand. I did get some clues as to why I test negative so far for XMRV. I got answers or “almost answers” to many questions about this creeping retrovirus, XMRV. Here I am listing my observations. I will post a link to Dr. Mikovits’ presentation as soon as it is available.

  • The retrovirus(s) has a high level of sequence diversity or different strains. The NIH (Alter and Lo) found a P (polytropic) MRV strain. This means that if you are infected with the PMRV strain you will currently test negative at The Whittemore Peterson Institute (WPI). Mikovits is working to develop more accurate testing for both strains. She hopes to have a test for PMRV by June 1, 2011.
  • It takes up to 45 days to grow a culture from blood, if the retrovirus is in the blood at the time.
  • XMRV leaves the blood and hides out elsewhere in the body until you are stimulated with another infection. [This could explain that the early outbreaks at Incline Village, NV, Lyndonville, NY and Raleigh, NC were caused by a secondary contagious infection superimposed on an existing XMRV infection.] Replication of XMRV is stimulated by inflammation and hormones.
  • There do seem to be clusters of 20 to 400 patients in outbreaks in specific locales.
  • Possible infections that enable XMRV to multiply would include EBV, HHV6, borrelia, babesia, bartonella, other?
  • In families where there is XMRV infection 30% will develop severe mononucleosis (EBV) at puberty and never recover.
  • If you test negative for XMRV in blood it may be because XMRV is not actively replicating in the blood. Dr. Cheney has suggested getting a flu shot which may activate the XMRV.
  • In chimp studies the virus very quickly left the blood and went into reservoirs, lymph node, spleen, liver – maybe thyroid, sex organs, adrenal glands, salivary glands, brain.
  • Current studies are ongoing (Eva Sapi) to see if there is an animal vector (mouse, tick) that might carry XMRV. [See Dr. Timothy Luckett
  • Dr. Jamie Deckoff-Jones, M.D. Director of Clinical Services
    Clinical Advisors will be
    Joseph Brewer, M.D. Infectious Disease
    Jack Burks, M.D. Neurology
    Marcus Conant, M.D. HIV
    Robert Fredericks, M.D. Endocrinology
    Michael Snyderman, M.D. Oncology
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