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Nitric oxide

Posted by Cort Johnson

The funder of big, complex and expensive studies whose costs often run into the millions of dollars, the National Institutes of Health (NIH) presents a resource like no other.  It’s never been easy to secure an NIH grant; for one thing, substantial data backing up one’s hypothesis is needed – which means researchers need to access substantial sums of money before they apply for the grant.  The pre-grant stage is where non-profit organizations, which can provide seed money (about $100,000) for researchers to get the data they need to apply, shine.

Getting the preliminary data is just the beginning, though. 

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Martin Pall, Ph.D

Martin Pall’s NO/ONOO Theory: Part II – Treatments Predicted to Assist in Chronic Fatigue Syndrome (ME/CFS)

Thirty agents or classes of agents predicted to down-regulate NO/ONOO cycle biochemistry:

Agent or Class of Agents Clinical Trial Data or Clinical Observation/Anecdotal Reports

  • Vitamin C (ascorbic acid) Clinical Trial Data
  • Selenium – None
  • Tocopherols/Tocotrienols Anecdotal Reports
  • Carotenoids – None
  • Flavonoids – Clinical Trial Data
  • Reductive stress relieving agents – Clinical Trial Data
  • Mitochondrial regeneration agents – Clinical Trial Data
  • L-Carnitine/Acetyl-L-carnitine – Clinical Trial Data
  • Hydroxocobalamin/B12 – Clinical Trial Data
  • Folic acid – Clinical Trial Data
  • Vitamin B6/pyridoxal phosphate – Anecdotal Reports
  • Riboflavin – None
  • Other B vitamins – None
  • Glutathione/glutathione precursors – Clinical Observations
  • alpha-Lipoic acid – None
  • Magnesium – Clinical Trial Data
  • SOD minerals/zinc,manganese, copper – None
  • NMDA antagonists – Clinical Trial Data
  • Inosine/uric acid – None
  • Taurine – None
  • Riluzole – None
  • Long chain omega-3 fatty acids – Clinical Trial Data
  • Agents that lower NF-kappa B activity – Anecdotal Reports
  • Curcumin – None
  • Algal supplements – Clinical Trial Data
  • Hyperbaric oxygen – Clinical Trial Data
  • Minocycline and Other Tetracyclines – Clinical Observations
  • Creatine – None
  • Lowered vanilloid activity – None
  • Carnosine – None
  • TRH – Clinical Observations

You will note that there is clinical trial data on the efficacy of 12 of these agents or classes of agents, and there are clinical observations and/or anecdotal evidence of efficacy of six others.… Read More