What'd they start you at?
If dose is too high, you may have that as well.
Thank you Iavonia . She started me on 5 mg ...is not a lot.
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What'd they start you at?
If dose is too high, you may have that as well.
Physiological steroid replacement definitely helped my hypoglycemia. The best results I have had though are on a combination of dexamethasone and hydrocortisone. The dex is a longer acting steroid which provides a much steadier base and eliminates a lot of the ups and downs that taking HC alone can create.
Steroids are a critical part of the immune response. It's the large, pharmacological doses that are immune suppressive and to be avoided with chronic infections. But you'll never get rid of infections with insufficient cortisol either. Too little is just as bad as too much.
My HPA axis is still dysregulated so I go on and off the steroids as needed. It's not hard to wean when my own cortisol production is good and my stress levels are low.Hi Ema . Did you have trouble getting off the HC again??
No, I don't take or need HC, I have too much Cortisol and Adrenaline, but too little Noradrenaline.Yes I have OI for sure. That's actually the hardest . I also read that it is hard on the adrenals cause when you have too little bloodvolume your adrenals need to create more noadrenaline to pump the blood to the head. So you need to create more cortisol and your adrenals start to fatigue . Need to find out where I read it :-/
Did you take HC??
Good point, adrenal function is heavily dependant on all of: Methylation; R5P (indirectly); P5P (directly); Vitamin C.I've been able to resolve my hypoglycemia with methylation treatment. I believe the hypoglycemia is related to the adrenals just like you're all discussing. My adrenals were flat-lined - among the very worst my naturopath had ever seen. I was never able to tolerate any kind of adrenal glandular without getting anxious. So for a long time, I just supplemented with electrolytes, as those will leak out when you have weak adrenals.
I believe methylation treatment is helping my adrenals. Based on the amount of electrolyte supplementation I've been able to reduce, and a change for the better in my sleep cycle, my adrenals are about 50% better. My hypoglycemia is pretty much non-existent as long as I eat real food and nothing sugary. I do follow a balanced Zone type diet, where each meal or snack is protein, carbs and fat.
I can now go 4-6 hours between meals, like a normal person.
No, I don't take or need HC, I have too much Cortisol and Adrenaline, but too little Noradrenaline.
I you do remember the source you will have to post it so we can all take a look.
Smiles,Have u had adrenaline and noradrenaline tested?
I didnt think testing for these would be accurate due to their half lives being so short as in minutes? Just someone getting a blood test for these and recieving a needle (fear factor) could increase their levels, alterating the measurements rather quickly?
Smiles,
with the conventional test yes, that would be true. Though I have no fear whatsoever of needles, feel no stress around medics, I am more likely to notice their tie colour or eye colour than the needle. This results form decades of experience of being jabbed.
The particular tests I had were platelet rather than serum tests - they have the advantages of giving a two hour average and not being impacted by level changes seconds ago.
I don't have a strong opinion but I do have two concerns. The first is that those tests look for downstream metabolites of the Neurotransmitters, not the actual hormones, hence if vitamin status / methyl status is not right I wonder how accurate they are. The second is that with Polyuria a much higher percentage of the test sample is water, and it means that larger multipliers are involved in the calculation - my gut hunch is that any inherent error in the instrumentation is likely to be magnified when people are producing 5-10-15 litres of urine per day rather than the usual 2.I have heard of people doing urine tests for similar neurotransmitters etc. What's your opinion on these types of tests for accuracy etc?
I don't have a strong opinion but I do have two concerns. The first is that those tests look for downstream metabolites of the Neurotransmitters, not the actual hormones, hence if vitamin status / methyl status is not right I wonder how accurate they are. The second is that with Polyuria a much higher percentage of the test sample is water, and it means that larger multipliers are involved in the calculation - my gut hunch is that any inherent error in the instrumentation is likely to be magnified when people are producing 5-10-15 litres of urine per day rather than the usual 2.
I would very much like to see some hard science done, comparing these urine based measures with 'reliable method' and between ME patients and the healthy population.
I've been able to resolve my hypoglycemia with methylation treatment. I believe the hypoglycemia is related to the adrenals just like you're all discussing. My adrenals were flat-lined - among the very worst my naturopath had ever seen. I was never able to tolerate any kind of adrenal glandular without getting anxious. So for a long time, I just supplemented with electrolytes, as those will leak out when you have weak adrenals.
I believe methylation treatment is helping my adrenals. Based on the amount of electrolyte supplementation I've been able to reduce, and a change for the better in my sleep cycle, my adrenals are about 50% better. My hypoglycemia is pretty much non-existent as long as I eat real food and nothing sugary. I do follow a balanced Zone type diet, where each meal or snack is protein, carbs and fat.
I can now go 4-6 hours between meals, like a normal person.
Very interesting.
Maybe you could explain exactly what and how you took it. I'm new to all this...
Unfortunately, there is no easy way to explain what I'm doing. Basic methylation supplements are the active forms of B12 and folic acid. But you don't want to start messing around with your methylation cycle without a lot of research and without a good doctor.
That being said - you can start with the Methylation Made Easy videos in my signature links below to get a basic understanding of the concept of what is methylation, how does poor methylation cause ME/CFS (and about 30 other diseases) and how to fix it.
Once you've grasped that, I have many other useful documents and links in my signature pertaining to methylation.
Many of us on here are trying various methylation treatments with various degrees of success in many areas.
Since a relapse that I have for a year now. I need to eat something every 2 hours otherwise I lose it completly.
Extremly tired. Super confused . Stressed etc. Heavy derealistion. Need to lay down instantly. Once I eat it gets better. Not perfect but it calms down.