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23andme & Chronic insomnia and family history of psychiatric/CNS disorders

Messages
211
Well...I just started getting tests.

White blood cell count seems on the low side (bottom of the range or below) and red blood cells doesn't look too goo either.

Iron seems normal, homocysteine is on the bottom of the range (too much b12? too much b6?), cholesterol is intermediate risk..

maybe it's an allergy or anemia, or some vitamin deficiency, or some viral ifnection (i dont feel sick but wake up with a stuffy nose) ....

do you have any idea where I can go from here? I'm thinking of going to a heamatologist to rule out anemia or some alergy...

Eritrocytes 5.27 x10^6 /ul [4.5-5.9]
Hemoglobin 14.8 g/dL [13.0-17.5]
Hematrocyte 45.9% [42.0-52.0]
V.G.M. 87.1 fL [80.0-96.0]
H.G.M. 28.0 pg [28.0-33.0]
C.M.H.G. 32.2 g/dL [33.3 - 36.0]
R.D.W. 14.1% [<14.9]

Leucocytes 5.25x10^3/ul [4.40-11.30]
Neutrophyles 42% [50-70]
Eosinophyles 6% {2.00-4.00]
Basophyles 1% [<1.00]
Lymphocytes 45% [25.00-40.00]
Monocytes 6% [2.00-8.00]
Plaques 195x10^3/ul [150-400]

Reticulocytes 1.2% [0.7-1.7]

Iron 121ug/dL [33-193]
Transferrine 233.0 mg/dL [200.0-360]

Cholesterol total 215mg/dL
Cholesterol LDL 157mg/dL (115-159 is moderate risk)
Triglicerides 55mg/dL [40-160]
Homocysteine 4.94 umol/L [5.00-12.00]

Sodium 142 mEq/L [136-145]
Potassium 4.3 mEq/L [3.5-5.1]
Chlore 102 mEq/L [98-107]
Calcium 9.5 mg/dL [8.6-10]
Magnesium 2.2 mg/dL [1.6-2.6]
 
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Messages
43
These tests will not help you with your insomnia. You need to get the 23andme test.

The low homocysteine is a signal you need to get your genetic profile to figure out what is going on.

But if you want to go down the slow road of blood testing:
Serum B12
MethylMalonic Acid Test
Folate

If you want to see how much my genetic profile helped me:
http://methylmutant.blogspot.com/
 
Messages
211
@Methyl Health, i've posted it in the beginning my 23andme. Im going to read your blog, seems interesting. Why the MethylMalonic Acid? When you say Serum B12, do you mean Cyanobocalamin? Should I test as well for methylb12,adenosylb12,methylfolate? Thanks a lot!


Ive started to read this afternoon Amy Yasko's "Autism Pathways to recovery". Its a very interesting book but the testing and supplements mentioned are extremely expensive. Has anyone followed it rigorously?




I'm posting again my 23andme but im also attaching a PDF which is better to read...

these are the results from MTHFRSupport because they seem more complete than genetic genie:

Detox
CYP1A1*2C A4889G rs1048943 C TT -/-
CYP1A1*4 C2453A rs1799814 T GG -/-
CYP1A2 C164A rs762551 C AC +/-
CYP1B1 L432V rs1056836 C CG +/-
CYP1B1 N453S rs1800440 C CT +/-
CYP1B1 R48G rs10012 C CG +/-
CYP2A6*2 A1799T rs1801272 T AA -/-
CYP2C19*17 rs12248560 T CC -/-
CYP2C9*2 C430T rs1799853 T CC -/-
CYP2C9*3 A1075C rs1057910 C AA -/-
CYP2D6 S486T rs1135840 G GG +/+
CYP2D6 T100C rs1065852 A GG -/-
CYP2D6 T2850C rs16947 A AG +/-
CYP2E1*1B G9896C rs2070676 G CC -/-
CYP2E1*4 A4768G rs6413419 A GG -/-
CYP3A4*1B rs2740574 C TT -/-
CYP3A4*3 M445T rs4986910 G AA -/-
GSTM1 rs1056806 T CC -/-
GSTP I105V rs1695 G AA -/-
GSTP1 A114V rs1138272 T CC -/-
NAT1 A560G(?) (R187Q) rs4986782 A GG -/-
NAT2 A803G (K268R) rs1208 G AA -/-
NAT2 C190T (R64W) rs1805158 T CC -/-
NAT2 G590A (R197Q) rs1799930 A AG +/-
NAT2 G857A (G286E) rs1799931 A GG -/-
NAT2 T341C (I114T) rs1801280 C TT -/-
SOD2 rs2758331 A AA +/+
SOD2 rs2855262 T CT +/-
SOD2 A16V rs4880 G GG +/+
PON1 Q192R rs662 C CT +/-

TONGUE TIE / Cleft Palate
CTH S4031I rs1021737 T GT +/-
IRF6 rs987525 A AC +/-
IRF6 rs861020 A AG +/-
RARA rs7217852 G AA -/-
TBX22 rs41307258 A T -
TBX22 rs28935177 T A -

Allergy/Mold
HLA rs7775228 C CT +/-
HLA rs2155219 T GG -/-

IgE
IL-13 C1112T rs1800925 T CC -/-
DARC rs2814778 C TT -/-
CD14 rs2569191 C CC +/+
SOCS-1 -820G>T rs33977706 A CC -/-
FCER1A rs2251746 C CT +/-
RAD50 rs2040704 G AA -/-
RAD50 rs2240032 T CC -/-

IgG
FCGR2A rs1801274 A AG +/-
GSTM3 V224I rs7483 T CT +/-

IgA
TRAF1 rs3761847 G AG +/-
IRF5 rs4728142 A GG -/-
IGF1R rs2229765 A AG +/-
IFIH1 (HLA) rs1990760 C CT +/-
HLA rs9271366 G AA -/-
CFH rs6677604 A AG +/-
HLA-DQA2 rs9275224 A AA +/+
MTC03P1 rs9275596 C CT +/-
PSMB8 / TAP1 / TAP2 rs9357155 A GG -/-
HLA-DPB2 / COL11A2P rs1883414 A AG +/-

Clotting Factors
CETP rs1800775 C AC +/-
CYP4V2 rs13146272 C AC +/-
GP6 rs1613662 G AA -/-
ITGB3 T196C rs5918 C TT -/-
KNG I598T rs2731672 T CC -/-
NR1I2 rs1523127 C AA -/-
SERPINC1 rs2227589 T TT +/+
HRG rs9898 T CT +/-
F11 rs2289252 T CC -/-
F10 113777509 rs3211719 G AA -/-
F7 A353G rs6046 A GG -/-
F2 (Prothrombin 20210A) i3002432 A GG -/-
F5 (Factor V Leiden) rs6025 T CC -/-
F9 G580A rs6048 G A -

Methylation
ACE Del16 rs4343 G AG +/-
ADD1 G460W rs4961 T GG -/-
ACAT1-02 rs3741049 A GG -/-
AGT M235T/C4072T rs699 G GG +/+
AHCY-01 rs819147 C TT -/-
AHCY-19 rs819171 C TT -/-
BHMT rs6875201 G AA -/-
BHMT-02 rs567754 T CT +/-
BHMT-08 rs651852 T CT +/-
BHMT R239Q rs3733890 A GG -/-
CBS A13637G rs2851391 T TT +/+
CBS C19150T rs4920037 A GG -/-
CBS C699T rs234706 A GG -/-
COMT rs6269 G AA -/-
COMT -61 P199P rs769224 A GG -/-
COMT H62H rs4633 T CT +/-
COMT V158M rs4680 A AG +/-
DAO rs2070586 A GG -/-
DAO rs3741775 C AC +/-
DHFR rs1643649 C CT +/-
FOLR1 rs2071010 A GG -/-
FOLR2 rs651933 A GG -/-
FOLR3 rs7925545 G AA -/-
FUT2 rs492602 G AA -/-
FUT2 rs601338 A GG -/-
FUT2 rs602662 A GG -/-
G6PD rs1050828 T C -
G6PD rs1050829 C T -
GAD1 rs3749034 A GG -/-
GAD1 rs2241165 C TT -/-
GAD1 rs769407 C CG +/-
GAD1 rs2058725 C TT -/-
GAD1 rs3791851 C CT +/-
GAD1 rs3791850 A GG -/-
GAD1 rs12185692 A AC +/-
GAD1 rs3791878 T GT +/-
GAD1 rs10432420 A GG -/-
GAD1 rs3828275 T CT +/-
GAD1 rs701492 T CT +/-
GAMT rs17851582 A GG -/-
GAMT rs55776826 T CC -/-
GIF (TCN3) rs558660 A AG +/-
MAO A R297R rs6323 T T +
MTHFD1 C105T rs1076991 C CT +/-
MTHFD1 G1958A rs2236225 A AG +/-
MTHFD1L rs11754661 A GG -/-
MTHFD1L rs17349743 C TT -/-
MTHFD1L rs6922269 A AG +/-
MTHFD1L rs803422 A AG +/-
MTHFR 3 P39P rs2066470 A GG -/-
MTHFR A1298C rs1801131 G TT -/-
MTHFR A1572G rs17367504 G AA -/-
MTHFR C677T rs1801133 A AG +/-
MTHFR G1793A (R594Q) rs2274976 T CC -/-
MTHFR rs13306560 T CC -/-
MTHFR rs1476413 T CC -/-
MTHFR rs17037390 A GG -/-
MTHFR rs3737964 T CC -/-
MTHFR rs4846048 G AA -/-
MTHFR rs4846049 T GG -/-
MTHFS rs6495446 C CC +/+
MTR A2756G rs1805087 G AG +/-
MTRR A66G rs1801394 G AG +/-
MTRR K350A rs162036 G AA -/-
MTRR-11 A664A rs1802059 A GG -/-
MTRR rs1532268 T CC -/-
MTRR rs3776467 G AG +/-
MTRR rs9332 A GG -/-
NOS2 rs2297518 A AG +/-
NOS2 rs2274894 T GT +/-
NOS2 rs2248814 A AG +/-
NOS3 rs1800783 A AA +/+
NOS3 rs1800779 G GG +/+
NOS3 rs3918188 A CC -/-
PEMT rs4244593 T GG -/-
PEMT rs4646406 A AA +/+
PEMT rs7946 C TT -/-
SHMT2 rs34095989 A AA +/+
TCN1 rs526934 G AG +/-
TCN2 C766G rs1801198 G CG +/-
VDR Bsm rs1544410 T CC -/-
VDR Taq rs731236 AA +/+

Celiac Disease/Gluten Intolerance
HLA rs2858331 G AG +/-
HLA DQA1 rs2187668 T CC -/-

Thyroid
CTLA4 rs231775 G AA -/-
FOXE1 rs1867277 A AG +/-
FOXE1 rs10984009 A AG +/-

Eye Health
BCMO1 rs4889294 C TT -/-
BCMO1 R267S rs12934922 T AA -/-
BCMO1 A379V rs7501331 T CT +/-

Mitochondrial Function
ATP5g3 rs36089250 C TT -/-
ATP5c1 rs1244414 T CC -/-
COX5A rs8042694 G AA -/-
COX6C rs4626565 C TT -/-
NDUFS3 rs4147730 A AG +/-
NDUFS7 rs2332496 A AA +/+
NDUFS7 rs1142530 T TT +/+
NDUFS7 rs7258846 T TT +/+
NDUFS7 rs809359 G AA -/-
NDUFS8 rs999571 A GG -/-
NDUFS8 rs2075626 C TT -/-
NDUFS8 rs1051806 T CC -/-
UQCRC2 rs4850 A GG -/-
UQCRC2 rs11648723 T GT +/-

Other Immune Factors
4q27 Region rs6822844 T GG -/-
APOE rs429358 C TT -/-
ATG16L1 rs10210302 C CT +/-
GSDMB rs7216389 T CC -/-
HLA-DRB1 rs660895 G AA -/-
IL5 rs2069812 A AG +/-
IL-13 rs20541 A GG -/-
IL4R Q576R rs1801275 G AA -/-
MeFV A744S i4000409 A CC -/-
MeFV E148Q rs3743930 G CC -/-
MeFV F479L i4000403 C GG -/-
MeFV K695R i4000407 C TT -/-
MeFV M680I rs28940580 G CC -/-
MeFV M694I rs28940578 T CC -/-
MeFV M694V i4000406 C TT -/-
MeFV P369S rs11466023 A GG -/-
MeFV R761H i4000410 T CC -/-
STAT4 rs10181656 G CC -/-
TNF -308 rs1800629 A GG -/-
TNF -238 rs361525 A GG -/-
TYR (MeFV) V726A rs28940879 A GG -/-

Sulfonotransferase
SULT1A1 rs35728980 G GT +/-
SULT1A1 rs1042157 A AG +/-
SULT1A1 rs36043491 T CC -/-
SULT1A1 rs60749306 C TT -/-
SULT1A1 rs9282862 C TT -/-
SULT1A1 rs1042008 A GG -/-
SULT1A1 rs4149385 T CC -/-
SULT1A1 rs60701883 A CC -/-
SULT1A1 rs4149381 G TT -/-
SULT1A1 rs7192559 T CT +/-
SULT2A1 rs296366 T CT +/-
SULT2A1 rs11569679 T CC -/-
SULT2A1 rs4149452 T CC -/-
SULT2A1 rs4149449 T CC -/-
SULT2A1 rs2547231 C AC +/-
SULT2A1 rs11083907 A GG -/-
 

Attachments

  • Genetic_Genie_Detox_Profile.pdf
    39.7 KB · Views: 7
  • Genetic_Genie_Methylation_Profile.pdf
    60 KB · Views: 6
  • MTHFRSupport_Variant_Report_v1_-_95478945616494677.pdf
    137.6 KB · Views: 11
Messages
211
@Methyl Heal, I would have never looked into the angiotensin mutation, thanks! I have been suspecting of the NOS3 gene and a few times ive tried supplementing arginine+lysine and this gave me a full night of sleep for the first two or three times i use it in a row.
How did you find that study? It is really interesting because it is indeed Late onset insomnia that i have!

I have been told by doctors once or twice that my blood pressure was slightly elevated. They always said it could be anxiety.
I have heart palpitations quite often when i lay down and i can hear my heart pounding...sometimes ive felt like it skipped a beat.
The machine i have at home to read tension says my heartbrate and tension are excellent but it says a possible cardiac arrythmia was found...
My mother does have high blood pressure.

The stuff gets complicated when they start talkibg about sulphur and ammonia (and i also eat a lot of onions and garlic as a portuguese) and how they are release with arginine , ornithine and cytruline, and when starting methylation.

It seems unprobable to me all these probs come from mthfr because from what ive seen ud need a few +/+ on mthfr which i dont have, in order to get problems..maybe from mtr/mtrr...what do you think about my CBS, Vdr taq and GAD1 ?

Do you have any idea on what i could test to evaluate if indeed there is a problem with the angiotensin and the NOS3?

I found this study, could be interesting to read the full article..would anyobe have access?
http://www.ncbi.nlm.nih.gov/pubmed/21438754?dopt=Abstract

Congratulations on ur recovery, ive just read ur blog u came a long way, i hope to do the same...
 
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Messages
43
When I see lack of sleep I see people "hyped up" when they should not be, that makes me look at the HPA axis for any mutations. Hence the AGT mutation.

You sound like me with the heart palpitations and the Docs also said I needed to "relax" to lower my blood pressure. It does not work.

Your CBS mutation is significant, do not underestimate it. I think it is more important than the NOS or AGT. I have the same CBS SNP, homozygous. We will always have issues when eating foods high in cysteine, like onions and garlic. (I come from an italian household so this is hard for me as well.) I am going to do a detailed post on CBS and cysteine this week.

I did some testing on this last night...ugh. Here is what happened:
http://methylmutant.blogspot.com/2014/10/memo-to-myself-eating-onions-and-garlic.html

But if you want to try something which helps me...

See if you can go for a week or longer not eating any garlic, onions, red meat (fish is ok if you are not allergic), cabbage, kale, asparagus, and broccoli.
If you can cut out most of the items on this list it will help see if your insomnia will be helped.
http://www.livingnetwork.co.za/chelationnetwork/food/high-sulfur-sulphur-food-list/

And I do not know if you can buy this in Portugal:
http://www.amazon.com/Source-Naturals-Coenzymated-25mg-Tablets/dp/B0016HK3BC/
But if you can find Pyridoxal-5'-Phosphate this is what you need to assist the CBS SNP.

Tray taking 25mg in the morning and another 25mg at night.

Look at this pathway map for a while:
http://www.hindawi.com/journals/jt/2011/394970.fig.001.jpg

And read over this:
http://ajpheart.physiology.org/content/299/5/H1568

I have a different angiotensin mutation, ACE Deletion, which I think gives me different issues. And I have NOS2 and not NOS3. I have never really had any sleeping issues, poor sleep most times, but it is not classified as insomnia.
I think these ACE and NOS SNPs have an interaction with CBS mutations through cortisol stimulation, but another time for that one.

I will see if my friend can get me that other study.
 
Messages
211
@Methyl Health

I have this at home http://www.amazon.com/Country-Life-Pyridoxal-Phosphate-100-Count/dp/B0019GXQK0/ref=sr_1_1?s=hpc&ie=UTF8&qid=1414849685&sr=1-1&keywords=country life p5p

do you think it is the same as the one you posted? I can just split it in 2...

I am still reading through and summarizing amy yasko's book. I think it's a good place to learn this.

I have now reached the chapter where the discussion of bypassing snp mutations is. im summarizing the book for myself, ill prob make it available.

i still have not found a very strong direct correlation between my mutations and my symptoms. I understand though that my symptoms can come from a wide variety of mutations. So now I will start making up a plan to bypass my mutations.

One question is:
- how important is to follow the step before, namely changing diet and supporting liver/kidney and other organs? I suppose I wont see any difference if I start supplementing but havent done those changes in advance?

my main concern right now is i can't work, so no income and i dont feel mentally well to study...not even to hang out sometimes... can't really have a relationship right now either.

so im devoting some time to reading this book in hopes that i will experience soem relief.

Half of my problems could be solved if i solved my insomnia, so anoter question is:
- If I decide to start on some medication for insomnia/depression/anxiety, will I still be able to identify and correct my underlying problems coming from snp's? Or will these medications begin masking the symptoms and changing blood values of the molecules I need to make exams to?

by the way, appart from that AGT homozygoty, i also have an heterzygous mutation of ACE...
 
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43
First, I took down my blog, I was getting too many people emailing me and it was distracting me.

Yes, that Pyridoxal Phosphate you got is fine. You do not need to split it in half, just take one in the morning or at lunch. After a while you might try to take it at dinner. I feel like it helps me become more relaxed at night but that is just me. You might want to take 100mg a day as well if you feel some improvement. Any dose below 200mg is safe but always practice self awareness.

I also think the B6 might help because it also used to help the GAD1 enzyme which you also have a number of SNPs. Do not think of insomnia, depression, and seizure as different disorders, they are on the same spectrum.
http://onlinelibrary.wiley.com/doi/...sCustomisedMessage=&userIsAuthenticated=false

I do not like Yasko that much, not because I do not feel that she is not on the right track, but the supplements she sells makes me uneasy. And I feel she is overcomplicating a simple problem. She focuses on Autism as well which is a specific set of SNPs. You need to follow yourself, not any guru. Take what you need from them and move on.

No special order of diet is needed, just start taking the B6 and looking at the high sulfur foods you eat. If the B6 works you might see some changes but limiting the cysteine in the diet would help. Eating less will also help.

Taking any drug will complicate finding the root of the problem. I am not saying do not take them, just keep in mind that it will be more difficult to see if the B6 or other dietary/nutrition changes helps. You will still see the changes however. I did. These drug only help with the symptoms however.

You have a lot going on with your SNPs and it will take some time for you to understand them. I have been putting together a more complete pathway map and I will send a link when I am done.
 
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211
@Methyl Health , indeed I am not thinking of following step by step the yasko book, i just think its a good place to learn and become aware of this. i find it good she is complicating because this way i can have a good view of everything that is involved in this. but i surely am not going to do the thousand exams she asks for. i want to do some exams though, for baseline and monitoring.

i understand your concern on her supplement selling, i feel the same way.

did you take anything to support the gut, liver and kidney? i am especially interested in pre/probiotics and liver support. i will prob get some..also maybe some multivitamin, maybe some omega 3 with a 200mg diff between EPA and DHA.

indeed low seizure threshold, insomnia, parasomnias, anxiety, depression..this is all connected. i have talked with a veyr good neurologist abotu it in portugal and he feels the same way.

i had tried b6 before, thats why i have it. at the time i was on trazodone so like you said, i couldnt be sure of what was doing what. so going to give it another go.

your blog was interesting, pitty you took it down... so, if you put together that more complete pathway map please send me a link :)

giong to read some more...
 
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Messages
43
I take 10,000 IU Vitamin A and 5000IU Vitamin D3 to help bile production but I have some SNPs that demand that. This helps my gut since Bile is important to digesting fats and proteins.

All of this stuff is happening in the liver anyway so anything you do to help your methylation cycle helps your liver.

Also, I forgot to mention, focus on your homozygous SNPs first, not that the heterozygous are less important, but you will likely be more effected by the homozygous SNPs. Could you list only your Homozygous SNPs? I would be interested in comparing.
 
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211
This is something I havent understood yet:
The methylation cycle (and its sub cycles) happen exactly where? In the liver, in the gut, or all over the body?
How long would one whole cycle take? And its subcycles?

Here are my homozygous SNPs according to sterling app.

(+/+)
Detox

CYP2D6 S486T rs1135840 G GG +/+
SOD2 A16V rs4880 G GG +/+
SOD2 rs2758331 A AA +/+
Allergy/Mold
CD14 rs2569191 C CC +/+

IgA
HLA-DQA2 rs9275224 A AA +/+

Clotting Factors
SERPINC1 rs2227589 T TT +/+

Methylation
AGT M235T/C4072T rs699 G GG +/+
CBS A13637G rs2851391 T TT +/+
MAO A R297R rs6323 T T +
MTHFS rs6495446 C CC +/+
NOS3 rs1800783 A AA +/+
NOS3 rs1800779 G GG +/+
PEMT rs4646406 A AA +/+
SHMT2 rs34095989 A AA +/+

Mitochondrial Function
NDUFS7 rs2332496 A AA +/+
NDUFS7 rs1142530 T TT +/+
NDUFS7 rs7258846 T TT +/+
 
Messages
43
This is something I havent understood yet:
The methylation cycle (and its sub cycles) happen exactly where? In the liver, in the gut, or all over the body?
How long would one whole cycle take? And its subcycles?

Methylation happen a billion of times a second. Really, it does. And methylation is not one process. Methylation is anytime a methyl group is added to a compound. So it can happen anywhere in the body.

http://drlwilson.com/Articles/METHYLATION.htm
 
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211
but weren't you saying that all this methylation was happening in the liver, in the post before? Maybe I misunderstood

Im on chapter 6 of the book, in the first priority mutations.

I feel this already sums up and explains a lot, lets see what I got:
- With a CBS mutation more cysteine is generated, and when the cell detects a high level of cysteine it produces more taurine and less gluthatione. So it's common in people with CBS upregulations (mutation), to see low homocysteine levels. I have a CBS mutation, A13637G, my Homocysteine was low in my only test done to it and I also didnt feel good when I tried taurine (prob had to do with an already elevated taurine level)

- NOS mutation can exacerbate CBS ammonia problem coming from upregulations, as inneficient NOS activity can lead to lead to elevated ammonia levels on its own. I have NOS3 homozygous mutations and NOS2 heterozygous mutations.

- Ideally, two molecules of BH4 are needed for each molecule of ammonia in order to detoxify it. Increased ammonia will deplete BH4 and BH4 is needed to create nitric Oxide, which means there is a reciprocal impact here. It is also critical in regulating neurotransmitters. Insufficient BH4 will make the body produce peroxy nitrite or super oxide, which can create oxidative stress. So my already reduced nitric oxide from an impaired NOS2/NOS3 (iNOS and eNOS) function, will also be affected by this depletion of BH4 because of excess ammonia! On top of all this, the depleted BH4 will make my body produce super oxide and, lucky me, I have several mutations in SOD3! Fortunately for me I don't have a MTHFR A1298C mutation, that would complicate this even further.

- Lack of BH4 will cause mast cell degranulation and lead to higher histamine levels, with symptoms such as red hears and other hipersensitivity reactions.
I have been suspecting high histamine for a while now as my white cell markers are a bit strange (some elevated, some decreased), anti-histaminics make me sleep the normal 8-9 hours, make me sleep almost through the night and if i wake up im able to fall asleep again. I used to have red hears all the time ever since a child up until my 18yo or so.

This could explain a lot already, what do you think?
I'm going to test for ammonia, sulfur, taurine, and maybe some others recommended.

I think my problem is mainly in the the CBS and NOS part of the cycle, and also on SOD3...which is a pain because thats the super oxide dismutase INSIDE the mitochondria...maybe ill get some MitoQ
 
Messages
211
As far as I see this, I have to change my diet, taking out garlics and onions like you said.
Incorporate some molybdenum and where can I get BH4??
 
Messages
43
BH4 will take care of it self. Keep it simple, you just have to fix a few things and the gears get moving. SOD3 only needs maganese as a cofactor, and iron but that is usually no a problem with guys. Just work on th b6 and diet.

Yes, i was paraphrasing about the liver. It is just an important organ.
 
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211
@Methyl Health , Ok! Sounds good !! Thanks for the help!

Now I came across another question...

Decreased BDNF is linked to depression/anxiety/insomnia, so I thought I'd see if someone had investigated mutations on this.
I found an interesting article: http://weill.cornell.edu/news/pr/2013/09/researchers-tease-apart-workings-of-a-common-gene.html

after reading another article I think it is rs6265 what I need to be looking for.

Went here www.snpedia.com/index.php/Rs6265 and saw that genotype can be either A or G, but in 23andme it is either C or T. And I'm CC.

Why the difference in values?
 
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First, just to get the nomenclature correct; A gene can have many nucleotides. A SNP is a mutation in a SINGLE nucleotide, hence the term Single Nucleotide Polymorphism. So you can have one, or many SNPs in a single gene.

Yes, that SNP is being researched. Now I am making an educated guess at this as I do not fully understand the Val Met polymorphism so maybe someone can jump ing. I looked at my alelles and I found they were C,T which would correspond with the A,G that SNPedia provides. That would translate your C,C SNP to A,A.

So we are both fracked when it comes to BDNF. But I do not worry about this because it is a secondary neurotransmitter. You can see from this image that by increasing serotonin, which is what me are trying to do my supporting the methylation pathway, we increase BDNF by stimulating CREB which regulates the expression of genes.

Again, keep it simple.

fig11.jpg
 
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Some things in this world make no sense.

I startedngetting more and morr back pain, chnaged mattresses andnback pain was still there. Thought this must be related to my insomnia somehow.

Noticed i was still feeling sore ribs from a very old fall.

Went back to the doctor and he xrayed my back.

Turns out i have scoliosis. This could be the reason, atbleast the main reason.

Cheers guys.

This is ridiculous. I think it coincided with me stopping sports because of a meniscus injury. Theny back started hurting too...what a luck
 
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@Sherlock ill look into that when i get back home.

Turns out The spine is not bent where the impact was.i was reading the xray wrongly. So this must be genetic.

I am trying to find out if there is a connection between methylation and glutathipne depletion and scoliosis or ligament laxivity? Do you have any idea? Cant find anything on this