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Valentijn
I have results from 23andMe (via MTHFRSupport) for which I'd love help in determining what SNPs to focus on. I've had them for about a year, but I have been afraid to do anything because it was too overwhelming.
I do not have ME/CFS but was diagnosed and am being treated for Hashimoto's thyroiditis since 2002.
Thanks in advance for your help
Hi Vacuna,
If you can manage it, it would be easier if you could run your same 23andme file through
http://geneticgenie.org/ and narrow down the amount of SNPs.
There is a methylation report and a detox report.
MTHFRsupport, bless their souls, have come up with all these other genes, but not necessarily an interpretation or treatment for them. They have a more general health focus than just methylation and ME/CFS.
Just off the top of my head, some other SNPs that genetic genie doesn't cover -
part 3 - HLA +/+ may want to try avoiding gluten if you don't already
part 2 - ACE Del 16 +/+ may have problems with hypertension and cardiovascular disease. may want avoid excessive salt.
part 3 - you have three thyroid genes, so that would corroborate thyroid disease (also MTHFR C677T would too)
part 3 - PEMT rs4646406, I have this same one, but it's listed with the risk allele T, so AA is -/-. Not sure why yours is reporting the opposite, or if I made an error on mine.
Anyway, this would affect folate and choline metabolism (from SNPedia):
[
PMID 19737740] Associations of folate and choline metabolism gene polymorphisms with orofacial clefts
[
PMID 21429654] Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility
Anyway, it looks like you would supplement with folate and choline for that, which you would already do as part of a methylation protocol.
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I've been able to heal my autoimmune thyroiditis (same as Hashi's) with methylation treatment. I'm off my med and all my labs are normal.
According to Ben Lynch 99% of people with thyroid problems have MTHFR. Mercury is also a problem, as well as chlorine, fluoride (in our water) and bromide (in bread). Those last three replace the iodine that the thyroid is looking for, so if you can avoid those, it should help. The mercury will come out as you kill any bad gut bugs, and then do methylation treatment (folate and B12 and co-factors).