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An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity.

osisposis

Senior Member
Messages
389
Psychoneuroendocrinology. 2014 Feb;40:140-50. doi: 10.1016/j.psyneuen.2013.11.012. Epub 2013 Nov 24.
An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity.
Dantoft TM1, Elberling J2, Brix S3, Szecsi PB4, Vesterhauge S5, Skovbjerg S2.
Author information
Abstract
BACKGROUND:

Multiple chemical sensitivity (MCS) is a medically unexplained condition characterized by reports of recurrent unspecific symptoms attributed to exposure to low levels of common volatile chemicals. The etiology of MCS is poorly understood, but dysregulation of the immune system has been proposed as part of the pathophysiology.
OBJECTIVE:

To compare plasma levels of cytokines in Danish MCS individuals with a healthy, sex- and age-matched control group.
METHOD:

Blood samples were obtained from 150 un-exposed MCS individuals and from 148 age- and sex-matched healthy controls. Plasma concentrations of 14 cytokines, chemokines and growth and allergen-specific IgE were measured. All participants completed a questionnaire including questions on MCS, psychological distress, morbidities and medication use at the time of the study.
RESULTS:

Plasma levels of interleukin-1β, -2, -4, and -6 were significantly (P<0.001) increased in the MCS group compared with controls, tumor necrosis factor-α was borderline significantly (P=0.05) increased and interleukin-13 was significantly decreased (P<0.001).
CONCLUSION:

MCS individuals displayed a distinct systemic immune mediator profile with increased levels of pro-inflammatory cytokines and interleukin-2 and inverse regulation of Th2 associated cytokines interleukin-4 and interleukin-13 suggestive of low-grade systemic inflammation, along with a deviating Th2-associated cytokine response not involving IgE-mediated mechanisms.

Copyright © 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:

Case–control studies; Cytokines; Immunological regulation; Multiple chemical sensitivity; Sickness behavior

http://www.ncbi.nlm.nih.gov/pubmed/24485486
 

jason30

Senior Member
Messages
513
Location
Europe
Thanks for sharing.
Interesting for me with Fibromyalgia and MCS because pro-inflammatory cytokines plays also a role by Fibromyalgia.