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Long-time lurker, first-time poster.
Since 23andme testing last summer, I have not made much progress on my own--6 months on Rich van K’s protocol and could not detect any change, much less improvement. I am hoping that knowledgeable and experienced people here might have comments or suggestions for me.
Here are my detox and methylation SNPs returned by MTHFRSupport (homozygous are bolded):
DETOX
Gene & Variation rsID # Risk Allele Your Alleles & Results
CYP1B1 L432V rs1056836 C CG +/-
CYP1B1 N453S rs1800440 C CT +/-
CYP2C19*17 rs12248560 T CT +/-
CYP2C9*3 A1075C rs1057910 C AC +/-
CYP2D6 S486T rs1135840 C CG +/-
CYP2D6 T2850C rs16947 A AA +/+
GPX3 rs8177412 C CT +/-
GSTP1 A114V rs1695 G AG +/-
NAT2 A803G (K268R) rs1208 G GG +/+
NAT2 T341C (I114T) rs1801280 C CC +/+
SOD2 rs2758331 A AC +/-
SOD2 A16V rs4880 G AG +/-
PON1 Q192R rs662 C CT +/-
METHYLATION
Gene & Variation rsID # Risk Allele Your Alleles & Results
ACE Del16 rs4343 G AG +/-
ADD1 G460W rs4961 T GT +/-
BHMT R239Q rs3733890 A AG +/-
CBS A13637G rs2851391 T TT +/+
CBS C19150T rs4920037 A AG +/-
CBS C699T rs234706 A AG +/-
COMT rs6269 G AG +/-
COMT H62H rs4633 T CT +/-
COMT V158M rs4680 A AG +/-
DAO rs2111902 G GG +/+
DAO rs3741775 C CC +/+
GAD1 rs769407 C CG +/-
GAD1 rs3791851 C CT +/-
GAD1 rs3791878 T GT +/-
GAD1 rs701492 T TT +/+
GAD1 rs769395 G AG +/-
GAD2 rs1805398 T GT +/-
GIF (TCN3) rs558660 A AG +/-
MTHFD1 C105T rs1076991 C CT +/-
MTHFD1 G1958A rs2236225 A AG +/-
MTHFD1L rs11754661 A NO CALL
MTHFD1L rs17349743 C CT +/-
MTHFD1L rs803422 A AG +/-
MTHFR A1298C rs1801131 G GG +/+
MTHFR rs12121543 A AA +/+
MTHFR rs13306560 T NO CALL
MTHFR rs1476413 T TT +/+
MTHFR rs3737964 T TT +/+
MTHFR rs4846048 G GG +/+
MTHFR rs4846049 T TT +/+
MTHFS rs6495446 C CT +/-
MTR A2756G rs1805087 G AG +/-
MTRR A66G rs1801394 G AG +/-
MTRR K350A rs162036 G AG +/-
MTRR-11 A664A rs1802059 A AG +/-
MTRR rs1532268 T CT +/-
MTRR rs3776467 G AG +/-
MTRR rs9332 A AG +/-
NOS1 rs3782206 T CT +/-
NOS2 rs2297518 A AA +/+
NOS3 rs1800783 A AT +/-
NOS3 rs1800779 G AG +/-
NOS3 rs3918188 A AC +/-
NOS3 G10T rs7830 T NO CALL
NOS3 T786C rs2070744 C CT +/-
PEMT rs4244593 T TT +/+
PEMT rs7946 C CT +/-
SHMT1 C1420T rs1979277 A AG +/-
SHMT1 rs9909104 C CT +/-
SHMT2 rs34095989 A AG +/-
TCN1 rs526934 G GG +/+
TCN2 C766G rs1801198 G CG +/-
TYMS rs502396 C CT +/-
VDR Bsm rs1544410 T CT +/-
My family seems to have methylation issues. We have a lot of autoimmune disease, gut problems, and depression. My father is currently in a nursing home, dying of unspecified dementia as did his father, and my mother was recently diagnosed with lupus. One brother was diagnosed with fibromyalgia and has a lot of migraines; the other has life-long depression and had hip replacement surgery at age 55 due to inexplicable femur necrosis. There is no family history of celiac disease.
My current symptoms include multiple sleep disorders and my gut does not work well (huge bloating, IBS, poor protein digestion, etc). It usually takes days to recover physically and mentally from even mild exercise. Body aches, anxiety, and life-long depression are kind of a background noise that rises and falls. I have random heart palpitations, maybe twice a week. Constant fatigue and cognitive issues (feeling overwhelmed by everything, dread about interacting with people, difficulty with initiating activity and focusing, brain fog) are the scariest to me. Everything is slowly getting worse over time.
From the reading I’ve done, it seems likely that I need folate and especially B12, but my symptoms did not improve when taking them along with the usual mineral suspects (Mg, Zn, Se, Mo, K). I’ve never had any obvious food problems other than raw onions, which seems like a very mild reaction if any with respect to possible CBS issues.
I stopped methyl supplements at the end of January and now take turmeric, probiotics and occasional Mg. Depression is becoming acute, so I am experimenting with SAMe—after two days I feel both calmer and more energized (even if it’s just a placebo, I’m grateful).
Thank you for any thoughts.
[edited to correct my misattribution of results]
Since 23andme testing last summer, I have not made much progress on my own--6 months on Rich van K’s protocol and could not detect any change, much less improvement. I am hoping that knowledgeable and experienced people here might have comments or suggestions for me.
Here are my detox and methylation SNPs returned by MTHFRSupport (homozygous are bolded):
DETOX
Gene & Variation rsID # Risk Allele Your Alleles & Results
CYP1B1 L432V rs1056836 C CG +/-
CYP1B1 N453S rs1800440 C CT +/-
CYP2C19*17 rs12248560 T CT +/-
CYP2C9*3 A1075C rs1057910 C AC +/-
CYP2D6 S486T rs1135840 C CG +/-
CYP2D6 T2850C rs16947 A AA +/+
GPX3 rs8177412 C CT +/-
GSTP1 A114V rs1695 G AG +/-
NAT2 A803G (K268R) rs1208 G GG +/+
NAT2 T341C (I114T) rs1801280 C CC +/+
SOD2 rs2758331 A AC +/-
SOD2 A16V rs4880 G AG +/-
PON1 Q192R rs662 C CT +/-
METHYLATION
Gene & Variation rsID # Risk Allele Your Alleles & Results
ACE Del16 rs4343 G AG +/-
ADD1 G460W rs4961 T GT +/-
BHMT R239Q rs3733890 A AG +/-
CBS A13637G rs2851391 T TT +/+
CBS C19150T rs4920037 A AG +/-
CBS C699T rs234706 A AG +/-
COMT rs6269 G AG +/-
COMT H62H rs4633 T CT +/-
COMT V158M rs4680 A AG +/-
DAO rs2111902 G GG +/+
DAO rs3741775 C CC +/+
GAD1 rs769407 C CG +/-
GAD1 rs3791851 C CT +/-
GAD1 rs3791878 T GT +/-
GAD1 rs701492 T TT +/+
GAD1 rs769395 G AG +/-
GAD2 rs1805398 T GT +/-
GIF (TCN3) rs558660 A AG +/-
MTHFD1 C105T rs1076991 C CT +/-
MTHFD1 G1958A rs2236225 A AG +/-
MTHFD1L rs11754661 A NO CALL
MTHFD1L rs17349743 C CT +/-
MTHFD1L rs803422 A AG +/-
MTHFR A1298C rs1801131 G GG +/+
MTHFR rs12121543 A AA +/+
MTHFR rs13306560 T NO CALL
MTHFR rs1476413 T TT +/+
MTHFR rs3737964 T TT +/+
MTHFR rs4846048 G GG +/+
MTHFR rs4846049 T TT +/+
MTHFS rs6495446 C CT +/-
MTR A2756G rs1805087 G AG +/-
MTRR A66G rs1801394 G AG +/-
MTRR K350A rs162036 G AG +/-
MTRR-11 A664A rs1802059 A AG +/-
MTRR rs1532268 T CT +/-
MTRR rs3776467 G AG +/-
MTRR rs9332 A AG +/-
NOS1 rs3782206 T CT +/-
NOS2 rs2297518 A AA +/+
NOS3 rs1800783 A AT +/-
NOS3 rs1800779 G AG +/-
NOS3 rs3918188 A AC +/-
NOS3 G10T rs7830 T NO CALL
NOS3 T786C rs2070744 C CT +/-
PEMT rs4244593 T TT +/+
PEMT rs7946 C CT +/-
SHMT1 C1420T rs1979277 A AG +/-
SHMT1 rs9909104 C CT +/-
SHMT2 rs34095989 A AG +/-
TCN1 rs526934 G GG +/+
TCN2 C766G rs1801198 G CG +/-
TYMS rs502396 C CT +/-
VDR Bsm rs1544410 T CT +/-
My family seems to have methylation issues. We have a lot of autoimmune disease, gut problems, and depression. My father is currently in a nursing home, dying of unspecified dementia as did his father, and my mother was recently diagnosed with lupus. One brother was diagnosed with fibromyalgia and has a lot of migraines; the other has life-long depression and had hip replacement surgery at age 55 due to inexplicable femur necrosis. There is no family history of celiac disease.
My current symptoms include multiple sleep disorders and my gut does not work well (huge bloating, IBS, poor protein digestion, etc). It usually takes days to recover physically and mentally from even mild exercise. Body aches, anxiety, and life-long depression are kind of a background noise that rises and falls. I have random heart palpitations, maybe twice a week. Constant fatigue and cognitive issues (feeling overwhelmed by everything, dread about interacting with people, difficulty with initiating activity and focusing, brain fog) are the scariest to me. Everything is slowly getting worse over time.
From the reading I’ve done, it seems likely that I need folate and especially B12, but my symptoms did not improve when taking them along with the usual mineral suspects (Mg, Zn, Se, Mo, K). I’ve never had any obvious food problems other than raw onions, which seems like a very mild reaction if any with respect to possible CBS issues.
I stopped methyl supplements at the end of January and now take turmeric, probiotics and occasional Mg. Depression is becoming acute, so I am experimenting with SAMe—after two days I feel both calmer and more energized (even if it’s just a placebo, I’m grateful).
Thank you for any thoughts.
[edited to correct my misattribution of results]
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