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Juice Me Up, Scotty!!!
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http://www.ncbi.nlm.nih.gov/pubmed/16610957
Abstract
And: http://www.ncbi.nlm.nih.gov/pubmed/16610949
In my opinion MAO A and B homozigous polymorphisms are also significant in psychophysical illness (HPA axis). I have both! My plan for these two is high dose curcumin.
Oh and I will add one that actually has "rs´s"! http://www.ncbi.nlm.nih.gov/pubmed/18079067
23and have that one bugged, what luck. http://snpedia.com/index.php/Rs6311
Abstract
OBJECTIVE:
This paper asks whether the presence of chronic fatigue syndrome (CFS) can be more accurately predicted from single nucleotide polymorphism (SNP) profiles than would occur by chance. METHODS:
Specifically, given SNP profiles for 43 CFS patients, together with 58 controls, we used an enumerative search to identify an ensemble of conjunctive rules that predict whether a patient has CFS.RESULTS:
The accuracy of the rules reached 76.3%, with the highest accuracy rules yielding 49 true negatives, 15 false negatives, 28 true positives and nine false positives (odds ratio [OR] 8.94, p < 0.0001). Analysis of the SNPs used most frequently in the overall ensemble of rules gave rise to a list of 'most important SNPs', which was not identical to the list of 'most differentiating SNPs' that one would calculate via studying each SNP independently. The top three genes containing the SNPs accounting for the highest accumulated importances were neuronal tryptophan hydroxylase (TPH2), catechol-O-methyltransferase (COMT) and nuclear receptor subfamily 3, group C, member 1 glucocorticoid receptor (NR3C1).CONCLUSION:
The fact that only 28 out of several million possible SNPs predict whether a person has CFS with 76% accuracy indicates that CFS has a genetic component that may help to explain some aspects of the illness. And: http://www.ncbi.nlm.nih.gov/pubmed/16610949
In my opinion MAO A and B homozigous polymorphisms are also significant in psychophysical illness (HPA axis). I have both! My plan for these two is high dose curcumin.
Oh and I will add one that actually has "rs´s"! http://www.ncbi.nlm.nih.gov/pubmed/18079067
The most compelling of these associations was with the A allele of -1438G/A (rs6311) which is suggested to have increased promoter activity in functional studies. Further, in silico analysis revealed that the -1438 A allele creates a consensus binding site for Th1/E47, a transcription factor implicated in the development of the nervous system. Electrophoretic mobility shift assay supports allele-specific binding of E47 to the A allele but not the G allele at this locus. These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS.
23and have that one bugged, what luck. http://snpedia.com/index.php/Rs6311