mgk
Senior Member
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The examine.com page for creatine says:
Has anyone tested this? It's especially appealing since creatine prices are much lower than a lot of the other supplements we're taking, probably owing to the fact that it's so popular with body builders.
Creatine is involved indirectly in whole body methylation processes. This is due to creatine synthesis having a relatively large methyl cost, as the creatine precursor known as guanidinoacetate (GAA) requires a methyl donation from S-Adenosyl Methionine (SAMe) in order to produce creatine. This may require up to half of the methyl groups available in the human body.[33][120]
Creatine supplementation will downregulate the body's own production of creatine by suppressing the enzyme which mediates the above conversion (Guanidinoacetate methyltransferase or GAMT)[121], and because of this it is thought that SAMe gets backlogged and is more available for other processes that require it.
Has anyone tested this? It's especially appealing since creatine prices are much lower than a lot of the other supplements we're taking, probably owing to the fact that it's so popular with body builders.