• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Hemex ISAC Hypercoagulation Profile?

Ema

Senior Member
Messages
4,729
Location
Midwest USA
I was looking to try to do this after reading that Heparin might also be good for the migraines I've been having again in full force...plus it should be a heck of a lot cheaper than the supplement lumbrokinase I've been using for coagulation issues. But it seems like I should test first...

So is this Hemex panel still the one? It looks like it's been bought out by Esoterix, which is a Labcorp company, but Labcorp says that they haven't run the ISAC panel since 2005.

Does anyone know if one of these tests is the replacement now?

http://www.hemex.com/prodserv/test_menu/index.asp

Or do I just order these individual tests through the regular Labcorp menu now?

Is anyone using sublingual or subQ heparin shots currently?

Thanks!


Immune System Activation of Coagulation (ISAC) Panel

Fibrinogen



180-310 mg/dl

Prothrombin Fragment 1+2



0.4-1.1 nM F1+2

Thrombin/Antithrombin Complexes



1.0-4.1 ug/l

Soluble Fibrin Monomer



0-17 mg/L

Platelet Activation by Flow:

CD62P



0-27 %

CD62P + ADP



39-80%

Platelet Activation Index



Normal
 
Last edited:

Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
@Ema

Your link doesn't work for me (I looked again and it think you pasted it in twice). I had the Hemex test and tried a followup with Quest doing the individual tests but it wasn't nearly as good--just gave positive or negative, not where I was in a range.

Esoterix still lists the test: http://www.hemex.com/prodserv/test_menu/phoenix/
320027
ISAC Panel (Fibrinogen Activity, Prothrombin Fragment 1+2, Thrombin/Antithrombin Complex, PA by Flow)

I did take low molecular weight, subcut heparin injections twice a day for 7 months, and it was a big help.

Sushi
 

Ema

Senior Member
Messages
4,729
Location
Midwest USA
@Ema

Your link doesn't work for me (I looked again and it think you pasted it in twice). I had the Hemex test and tried a followup with Quest doing the individual tests but it wasn't nearly as good--just gave positive or negative, not where I was in a range.

Esoterix still lists the test: http://www.hemex.com/prodserv/test_menu/phoenix/
320027
ISAC Panel (Fibrinogen Activity, Prothrombin Fragment 1+2, Thrombin/Antithrombin Complex, PA by Flow)

I did take low molecular weight, subcut heparin injections twice a day for 7 months, and it was a big help.

Sushi
Thanks, @Sushi. It does look like I pasted the link in twice so I've fixed that.

I don't know why they would say that they've not done the panel since 2005 since it's still listed. I guess I will find out when I go for the draw!

Did you bruise badly from the injections? Did you ever consider doing them sublingually? Why did you stop? Do you think the serrapeptase works as well?

Do you know the difference between regular and low molecular weight? I think the regular dose starts at 5000 units twice a day but the low molecular weight seems to come in mgs? Do you remember your dose by any chance?

Does it have to be preservative free?

So many questions but worth it if it will kill babs and save me $60/month on lumbrokinase...
 

Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
@Ema

I don't know the answers to most of the questions. My doctor at that time was in contact with Dr. David Berg and was following his advice as to how to treat me.

I had tiny bruises (stomach) from each injection but it didn't bother me. I don't think that there was a sublingual option at that time. I stopped because that was the protocol--some months on heparin and then switch to nattokinase. I think Berg has changed some of his recommendations since. I still take natto.

I don't remember my dose (years ago) and don't know the difference between low molecular weight and regular. Could your doctor get in touch with David Berg? Sorry I don't remember more.

Sushi
 

Symptomatic

Senior Member
Messages
197
Late to the party as usual...my doc is going to be ordering this test for me as well (if/when I see the exact test ordered, I'll let you know). Will be very interested to get my results, and hopefully to see yours as well.
 

Ema

Senior Member
Messages
4,729
Location
Midwest USA
Late to the party as usual...my doc is going to be ordering this test for me as well (if/when I see the exact test ordered, I'll let you know). Will be very interested to get my results, and hopefully to see yours as well.
My results weren't all that exciting. They actually didn't show much, if any, hypercoagulation. But I had also been taking lumbrokinase for years prior so that may have influenced the results. I did stop it for about a month prior.

I trailed low dose heparin as a sub for the expensive lumbrokinase but found it made me dizzy. Everything is making me dizzy right now though so I will try it again in the future once I get my OI issues under better control again.

I don't know what the optimal numbers are for the panel but I can post mine if you want to compare.
 

Symptomatic

Senior Member
Messages
197
Esoterix still lists the test: http://www.hemex.com/prodserv/test_menu/phoenix/320027 ISAC Panel (Fibrinogen Activity, Prothrombin Fragment 1+2, Thrombin/Antithrombin Complex, PA by Flow)

I did take low molecular weight, subcut heparin injections twice a day for 7 months, and it was a big help.

Yup, this is the one on my lab orders. I got my blood drawn today, so we'll see.

@Sushi - what exactly did you feel the heparin helped with?
@Ema - I'll PM you once I have my results.

Did either of you have issues with insurance covering the test?
 

Symptomatic

Senior Member
Messages
197
I also looked back at some old data. I had a lupus anticoagulation panel run way back in 2003:

PT: < 10 (range: 11-14.5)
PTT-LA: 42 (range: 0-52)
APTT: 27.6 (range 31-39)
APTT 1:1 NP: 29.2 (range 31-39)
Dilute Russells’s viper venom: 38.4 (range 0-45)
Thrombin time: 16.3 sec (range <18)
Heaxagonal Phase Phospholipids: <1.0 sec (range 0 – 8)

I'm thinking the faster PT and aPTT times indicate hypercoagulation? 2003 was a long time ago, so who knows what the condition of my blood is today.
 

Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
Yup, this is the one on my lab orders. I got my blood drawn today, so we'll see.

@Sushi - what exactly did you feel the heparin helped with?
@Ema - I'll PM you once I have my results.

Did either of you have issues with insurance covering the test?

Since "sticky blood" doesn't carry oxygen and nutrients to the cells very well, that is one possibility. I don't know enough science to go further than that. :cool:

I had very comprehensive private insurance at the time (Hemex was independent at the time) and it was covered. Now that Labcorp owns it, I don't know what the insurance situation is.

Best,
Sushi
 

drob31

Senior Member
Messages
1,487
Just a bump. Has anyone figured out what the ISAC tests are now? I'm currently investigating this path.
 

drob31

Senior Member
Messages
1,487
Bumping this one again as well. Anyone have luck pursuing this path? Thanks in advance.

I went down this path. I actually ended up contacting David Berg. He's retired though. He thinks hypercoagulation is caused by a virus like EBV or bacteria like Lyme. I had a low WBC count and he thought it could be viral.

I didn't really get very far with this. He ended up referring me to Ruth kris, but I only had 2 appointments with her. She tried treating me for EBV with Byron white eb/h6. My HHV6 titers were always a little elevated.

Ironically I got EBV twice last year. Or at least it reactivated. Since then im pretty ADHD about what's wrong with me, I jump from one thing to another.
 

Sparrowhawk

Senior Member
Messages
514
Location
West Coast USA
Thanks for the response and overview of your attempts along these lines. My reading so far this morning seems to run into dead ends, such as the fact the testing service recommended doesn't exist any more.
 

drob31

Senior Member
Messages
1,487
Thanks for the response and overview of your attempts along these lines. My reading so far this morning seems to run into dead ends, such as the fact the testing service recommended doesn't exist any more.


It sort of does. I had the ISAC panel don't by an AZ lab.

I had a cyrex autoimmune panel done before that which showed antiphospholipid antibodies. I went to a specialist who said I didn't have it. That's why I went down the hypercoagulation route. Apparently Lyme can cause it also.

I'm not even sure if I have hypercoagulation though, I feel like I'm more adrenal/hypothyroid.
 

aquariusgirl

Senior Member
Messages
1,732
I am wondering if there is a familial coagulation defect, or possibly APS or Hughes syndrome.
3 of my mother's siblings had strokes....one had a bleed on the brain after blood thinners. It put him in a coma.

In 2012, I did the ISAC panel. Fibrinogen was 508.. ( 160-420 )

2011 T/AT complexes 6.2 range was <4.1
cd62P = ADP 33% (40-100) L
Platelet Activation Index was Low

David Berg said I had a big problem....referred me to Ruth Kris.. and I never followed up with her.

I don't feel much from drugs taken orally. I seem to have an outsize biofilm problem too.

Thoughts?
 

Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
referred me to Ruth Kris.. and I never followed up with her.
My thought is to follow up with her. Was the blood thinner Coumadin? If so, it requires blood tests every few weeks and the levels can be very difficult to control. The new ones are much easier (and probably safer) to use.