Nice article I stumbled across today on the web:
http://www.drkaslow.com/html/immune_restoration.html
http://www.drkaslow.com/html/immune_restoration.html
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Thanks Justy this is a good explanation, of which I have been searching for.Nice article I stumbled across today on the web:
http://www.drkaslow.com/html/immune_restoration.html
What worries me from this study is that we should not be cooking in any oil whatsoever (even stir fry?) I don't fry much stuff eat a range of steamed vegie's. But diidnt think roasting stuff in the oven was any good either. So in terms of eating stir fry with protein (ie fish, chicken tofu or meat) it's out? Even with cold pressed olive oil??I have just been told that my TH1 immunity is seriously lowered, and my doctor has plans for me, but this article looks very comprehensive, with good explanations of what is going on and some suggestions for what to do about it, including studies showing the evidence of the various approaches.
Must remember to bookmark this. My doc has already suggested we should, at some point add in DHEA (and I am deficient) as it increases TH1 immunity. The only problem is I couldn't tolerate it before, but im not starting it straight away.
I have just been told that my TH1 immunity is seriously lowered, and my doctor has plans for me, but this article looks very comprehensive, with good explanations of what is going on and some suggestions for what to do about it, including studies showing the evidence of the various approaches.
Must remember to bookmark this. My doc has already suggested we should, at some point add in DHEA (and I am deficient) as it increases TH1 immunity. The only problem is I couldn't tolerate it before, but im not starting it straight away.
I have just been told that my TH1 immunity is seriously lowered, and my doctor has plans for me, but this article looks very comprehensive, with good explanations of what is going on and some suggestions for what to do about it, including studies showing the evidence of the various approaches.
Must remember to bookmark this. My doc has already suggested we should, at some point add in DHEA (and I am deficient) as it increases TH1 immunity. The only problem is I couldn't tolerate it before, but im not starting it straight away.
I think that's the way to go - I started with emptying a 10mg pill out and putting half back in - was too much so did a quarter, but its not exactly scientific is it? emptying out the powder and dividing it. At approx. 2mg a day I was weepy and raging.Can u get a 1mg strength dhea pill and slowly increase 1mg at a time until you get to the desired dose for you? ?
My herbalist used to give me this and while I was on her formula (which contained many other things, including ashwaganda) my recurrent lung infections became less and less. Last few weeks is the first time ive had a lung/chest infection in over two years.
What worries me from this study is that we should not be cooking in any oil whatsoever (even stir fry?) I don't fry much stuff eat a range of steamed vegie's. But diidnt think roasting stuff in the oven was any good either. So in terms of eating stir fry with protein (ie fish, chicken tofu or meat) it's out? Even with cold pressed olive oil??
I dont eat anything deep fried and only occasionally roast stuff. Also eat a half raw diet but! Our only option is steaming or broiling everything? I just dont think I can give up my stir fry with a little garlic, ginger and oil
http://en.wikipedia.org/wiki/Dehydroepiandrosterone
In women with adrenal insufficiency and the healthy elderly there is insufficient evidence to support the use of DHEA.[8][9
It is not known whether DHEA is safe for long-term use. Some researchers believe DHEA supplements might actually raise the risk of breast cancer, prostate cancer, heart disease, diabetes,[27] and stroke. DHEA may stimulate tumor growth in types of cancer that are sensitive to hormones, such as some types of breast, uterine, and prostate cancer.[27] DHEA may increase prostate swelling in men with benign prostatic hyperplasia (BPH), an enlarged prostate gland.[26]
DHEA is a steroid hormone. High doses may cause aggressiveness, irritability, trouble sleeping, and the growth of body or facial hair on women.[26] It also may stop menstruation and lower the levels of HDL ("good" cholesterol), which could raise the risk of heart disease.[26] Other reported side effects include acne, heart rhythm problems, liver problems, hair loss (from the scalp), and oily skin. It may also alter the body's regulation of blood sugar.[26]
DHEA is possibly unsafe for individuals experiencing the following conditions: pregnancy and breast-feeding, hormone sensitive conditions, liver problems, diabetes, depression or mood disorders, polycystic ovarian syndrome (PCOS), or cholesterol problems.[33] Individuals experiencing any of these conditions should consult with a doctor before taking.
Cancer
Some in vitro studies have found DHEA to have both antiproliferative and apoptotic effect on cancer cell lines.[53][54][55] The clinical significance of these findings, if any, is unknown. Higher levels of DHEA and other endogenous sex hormones are strongly associated with an increased risk of developing breast cancer in both pre- and postmenopausal women.[56][57]
With dhea supplementation its about taking a dose that gets you to an optimal level of dhea, so initially testing is required to work out the correct dose. I assume if the correct dose is used then the risk of cancers and other conditions from dhea use wouldnt be too different to healthy people with optimal dhea levels who dont supplement with dhea.
It seems that Justy has a dhea level well below whats considered normal which would bring about its own risks. My dhea levels were also once well below normal range, with adding extra dhea i have got it into an optimal range.
The side effects of dhea listed above mostly seem consistent with taking doses that would put dhea levels well above whats considered normal. Its a case of monitoring ones dhea levels to make sure they stay within normal ranges. Also important to monitor related hormones as dhea can also effect these too??
Tru heaps, but I guess thepoint is, DHEA is a hormone, steroid hormone and you dont want to muck about with it too much. And their is still inconclusive evidence on it. Its not like a vitamin or amino acid. Also Justy said it affected her emotionally. Their are lots of ways to improve the immune system without additional steroids.
There are a LOT of positive studies on DHEA use as well in the literature. Wikipedia is highly biased against DHEA in my opinion. I would not base my decision whether or not to use it based on that source.http://en.wikipedia.org/wiki/Dehydroepiandrosterone
In women with adrenal insufficiency and the healthy elderly there is insufficient evidence to support the use of DHEA.[8][9
It is not known whether DHEA is safe for long-term use. Some researchers believe DHEA supplements might actually raise the risk of breast cancer, prostate cancer, heart disease, diabetes,[27] and stroke. DHEA may stimulate tumor growth in types of cancer that are sensitive to hormones, such as some types of breast, uterine, and prostate cancer.[27] DHEA may increase prostate swelling in men with benign prostatic hyperplasia (BPH), an enlarged prostate gland.[26]
DHEA is a steroid hormone. High doses may cause aggressiveness, irritability, trouble sleeping, and the growth of body or facial hair on women.[26] It also may stop menstruation and lower the levels of HDL ("good" cholesterol), which could raise the risk of heart disease.[26] Other reported side effects include acne, heart rhythm problems, liver problems, hair loss (from the scalp), and oily skin. It may also alter the body's regulation of blood sugar.[26]
DHEA is possibly unsafe for individuals experiencing the following conditions: pregnancy and breast-feeding, hormone sensitive conditions, liver problems, diabetes, depression or mood disorders, polycystic ovarian syndrome (PCOS), or cholesterol problems.[33] Individuals experiencing any of these conditions should consult with a doctor before taking.
Cancer
Some in vitro studies have found DHEA to have both antiproliferative and apoptotic effect on cancer cell lines.[53][54][55] The clinical significance of these findings, if any, is unknown. Higher levels of DHEA and other endogenous sex hormones are strongly associated with an increased risk of developing breast cancer in both pre- and postmenopausal women.[56][57]
Unknown.
Well, if you're not supplementing it, it's likely low. Zinc deficiency will adversely affect immune function and TH1/TH2 balance:Unknown.
http://www.immunityageing.com/content/6/1/9Furthermore, the TH1/TH2 balance is affected by zinc. During zinc deficiency, the production of TH1 cytokines, in particular IFN-γ, IL-2, and tumor necrosis factor (TNF)-α is reduced, whereas the levels of the TH2 cytokines IL-4, IL-6, and IL-10 were not affected in cell culture models 46] and in vivo 47,48].
Thanks - good info!Well, if you're not supplementing it, it's likely low. Zinc deficiency will adversely affect immune function and TH1/TH2 balance:
http://www.immunityageing.com/content/6/1/9
Zinc deficiency also leads to excessive aromatase activity, causing higher levels of conversion of DHEA to estrogen, which could very well explain the rage and weepiness.