Hi, Liz.
I don't think you will need to raise folate or B12 because of adding glutathione. In fact, based on a recent study in Korea, I think that raising glutathione will make the B12 more effective, because it raises the affinity of part of the intracellular B12 processing for B12.
Taking it at night might be a good thing to try.
I haven't heard from very many people who have added glutathione to the methylation treatment. I do still believe that it is necessary to lift the partial block in the methylation cycle in order to get glutathione to stay up on a permanent basis, but as I have learned more about the problem of excitotoxicity in the early part of this treatment, as well as this new information about glutathione raising the B12 affinity, I have become more in favor of adding glutathione to the methylation protocol, either liposomal or acetyl glutathione. But I am concerned about making sure there is enough B2 and B3 when this is done, or it may shift the ratio of reduced to oxidized glutathione too low, and also rob other reactions of these nutrients, if they are in short supply.
Best regards,
Rich
I don't think you will need to raise folate or B12 because of adding glutathione. In fact, based on a recent study in Korea, I think that raising glutathione will make the B12 more effective, because it raises the affinity of part of the intracellular B12 processing for B12.
Taking it at night might be a good thing to try.
I haven't heard from very many people who have added glutathione to the methylation treatment. I do still believe that it is necessary to lift the partial block in the methylation cycle in order to get glutathione to stay up on a permanent basis, but as I have learned more about the problem of excitotoxicity in the early part of this treatment, as well as this new information about glutathione raising the B12 affinity, I have become more in favor of adding glutathione to the methylation protocol, either liposomal or acetyl glutathione. But I am concerned about making sure there is enough B2 and B3 when this is done, or it may shift the ratio of reduced to oxidized glutathione too low, and also rob other reactions of these nutrients, if they are in short supply.
Best regards,
Rich