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Hi, I'm Mike 20 years old and have been suffering from anxiety and depression that came out of NOWHERE one day and has plagued me ever since. i honestly at this point dont care if i have to take psych drugs to get relief at this point but i wanna make sure i get everything right with my methylation. i am compound heterozygous MTHFR C667T/ A1298C and heterozygous COMT VAL158MET. can someone please give me some sort of supplement regimen that treats these because im sick of feeling like this. i also came up as poor metabolizer for CYP2D6 so i know i have to watch if i take those drugs because ill have an increase risk of side effects. also i want to know is methylation something that has to be fixed before you go on antidepressants to ensure their efficency, and is there a possibility that if i fix this methylation problem i could feel better without drugs? honestly i was the most normal, outgoing, hilarious, fearless human around and was just so normal, and all i want to do is feel like a normal human being. i know that this experience has caused me to change and ill never feel exactly how i felt but that doesnt mean i cant feel normal and happy. so if anyone can help me out here it would be SO APPRECIATED... some supplements i should take, how much methylfolate is usually sufficent for someone with my mutations and stuff like that. also about if i have to fix this before the drugs can be successful thats a big worry of mine also. from what ive read i have increased dopamine and decreased serotonin and i know antipsychotics fix that but its not my desire in life to take antipsychotics for the rest of my life but if i had to i wouldnt care. SOMEONE HELP ME lol.... thanks guys