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My homozygous MTHFR SNPS:

Messages
43
These are my homozygous MTHFR SNPS:
MTHFR A1298C rs1801131 G GG +/+
MTHFR rs1476413 T TT +/+
MTHFR rs3737964 T TT +/+
MTHFR rs4846048 G GG +/+
MTHFR rs4846049 T TT +/+

I definitely see how this SNP effects me now. It seems I can lower my systolic blood pressure (This mornings reading went from 141 to 112) by taking riboflavin-5′-phosphate (FMN) and 3MG of 5-MTHF. I am going to do some more testing by just taking the Riboflavin but I wonder if we could talk about this. The 5-MTHF supplements are so much more expensive, I was thinking of going up to 5MG 5-MTHF and it will cost me about $30 per month. So with that price difference in mind I was wondering if I even need to take it if FMN can do it on its own.

I am having a hard time understanding the role and relationship of NADP+, NADPH, FAD, and FMN with MTHFR. It seems like NADPH is also a cofactor. Do I need to take Nicotinamide as well? Ugh.

I am wondering to if my lower blood pressure has more to do with how FMN affects Nitric Oxide coupling.

NOTE
: I do not worry about my diastolic BP, it seems it is irrelevant and that we should only focus on the systolic as a marker for health and hypertension.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
Methylfolate, almost certainly. Have you ever had neurotransmitter issues? (anxiety, depression, bipolar, OCD, autism spectrum, ADHD, wired/tired feeling, mood swings, migraines?) Those are all associated with MTHFR A1298C rs1801131 G GG +/+. So, methylfolate would be important unless all of those sound unfamiliar to your experience.

You might try Piping Rock for your methylfolate. They seem to have the least expensive Metafolin(R) brand methylfolate I've found.
 

PennyIA

Senior Member
Messages
728
Location
Iowa
This is what gets me nuts. I showed my primary care physician I have this mutation and they could not give two poops about it. Any ideas how I could convince them to give me a prescription?

My regular doc is with yours. I do see a methylation specialist via skype and telephone calls and he could prescribe the rx, but truly I'm mostly up to 15 mg per day now (though I have had periods where I needed a break and had to build back up)... so I buy it without an rx.
 

CFS_for_19_years

Hoarder of biscuits
Messages
2,396
Location
USA
NOTE: I do not worry about my diastolic BP, it seems it is irrelevant and that we should only focus on the systolic as a marker for health and hypertension.

Just a thought to keep in mind: Diastolic BP represents the baseline BP that your system experiences at all times and if it is too high, lets say, 90, there can be long-term consequences (heart disease, kidney disease, etc.)

http://blood-pressure.emedtv.com/diastolic-blood-pressure/diastolic-blood-pressure-p2.html

If the diastolic blood pressure is too high, a person is said to have high blood pressure, which is also known as hypertension. High blood pressure means that the diastolic blood pressure reading is higher than 90.

In people with high blood pressure, the small blood vessels in the vital organs are most affected over time. These blood vessels become scarred, hardened, and less elastic, which means that they are more likely to get blocked or rupture (leading to organ damage or even organ failure). This may happen as you get older, whether or not your blood pressure is too high. High blood pressure can speed up this process, so maintaining a normal blood pressure is a vital part of reducing the risk of a heart attack, stroke, or organ damage.

A person with a diastolic blood pressure reading between 80 and 89 has a condition called prehypertension.

This is what gets me nuts. I showed my primary care physician I have this mutation and they could not give two poops about it. Any ideas how I could convince them to give me a prescription?

Even if you could get your doctor to give you a prescription, there's no guarantee your insurance will cover it as it is classified as "medical food." Good for you if you can get it covered by insurance though.
 

Helen

Senior Member
Messages
2,243
This is what gets me nuts. I showed my primary care physician I have this mutation and they could not give two poops about it. Any ideas how I could convince them to give me a prescription?
A high homocysteine and/or low folate. There are lots of articles and studies of the enzyme activity and mutations in MTHFR A1298T that should convince your doctor.