Low doses of nutrients are good for prevention mostly while high doses are for treatment. Just like Vitamin C for cancer patients is not effective at low ranges. My main issue is mitochondrial insufficiency and therefore my basic aim is to restore them to levels that make my disability better. I've read about mitochondria alot as it has been my main focus all the time and the conclusion that many specialists agree on is that there is no treatment for mito disease and that supplements do prevention For mito decline at best.
I also believe this to be right tbh. So the supplements I listed are mainly building blocks and for protection I don't expect them to raise ATP to any relevant measure, my only hope basically is that the HGH and EPO could do that in combination with optimizing thyroid as there are few studies that claim they're able to induce mitochondrial biogenesis (creation of new mitos) and as there are no studies on such a combination in relation to ATP I'm aware that outcome will be unknown.
Left with mitochondrial disorder, it is the only option I see for myself except for staying ill listening to professionals who say inherited mitochondrial insufficiency is incurable. My wish is to disprove that consensus. I like Dr. Teitelbaums theories, but I believe that his treatment is not effective enough for mitochondrial disorders. Also I like Dr. Myhill and agree on many things she says and she's honest enough to say this to make patient expectancy realistic,
http://drmyhill.co.uk/wiki/How_Long_Before_I_Recover?
But again she doesn't use HGH, so I will have to see if this works out as it is my main hope in this protocol for my mitochondria.
Otherwise,
I will just have to die a heavily disabled man without having ever gotten all the wonderful joys of life, really i'm not willing to give that all up yet, at least not before I have failed with this deadly combination last try- protocol.
As for the others Thanks for your opinions, but I'm not able to answer them all individually right now.
Kind regards, amaru7
We need to have some understanding of the root cause of disease before we can utilize high dose nutrient support
. Yes, high dose vitamin C can be very beneficial for cancer treatment and many other chronic conditions if we know what we are treating. Dr. Amy Yasko recommends we use vitamin therapy as a low dose approach. Why? Because she know how the body works. If you have a slow liver and weak kidney function, will high dose vitamin therapy be a good idea? The simple is answer no, many have try this approach and failed miserably. I do feel there are exceptions to these rules. High dose lipid therapy has help me in many ways. But, if I had low cortisol or high cholesterol and the COMT+/+ issue, this therapy could be a problem. Alternative medicine techniques such as orthomolecular medicine that targets a wide range of conditions can also be beneficial for some but we need to look at all contributing factors as possible before we try these high dose nutritional type therapy.
See more here: http://www.nleducation.co.uk/resour...osis-the-mitochondrial-and-immune-connection/
What is the root cause of this Vicious Cycle?
Mitochondrial damage is a normal part of aging, but is accelerated in many metabolic disorders. Chronic deficiencies and gut imbalances can destroys the mitochondrial membranes and lead to the modern diseases we see today.
The liver is our most valuable organ, we can only survive one or two days if it shuts down. Some of the most import functions of the liver include: Clearing the blood of waste products, drugs, and other poisonous substances. The liver also produces immune factors and removes bacteria from the bloodstream to help combat infection. There are many inflammatory conditions that can affect the liver's detoxification process. The medical term hepatitis literally means inflammation of the liver. Chronic fatigue, and many other chronic illnesses can be aggravated by a buildup of toxins. Multiple chemical sensitivity can also be a problem that can include an intolerance to caffeine, alcohol, perfumes, and cleaning agents. These intolerance's tends to get progressively worsen over time and can be very damaging to the mitochondria.
The Sulfotransferase metabolism is very important in Phase II detoxification, which is responsible for the detoxification of many compounds. Some of these compounds are phenols, amines, sulfide, salicylates, food additives, and many other toxic molecules as well as nutritious foods considered to be very healthy. Malfunction of the
Phenol-Sulfotransferase (PST) enzyme can cause an overload of phase 2 toxins in the liver. These toxins can impair the brain causing fatigue and many other nervous system mitochondrial dysfunctions. These insufficiency can also have a impact on intercellular sulfate needed for proper cell function. Sulfate depletion can have a impact sulphur transferase and sulphite oxidase and possibly contribute to a functional deficiency. These enzyme's are also responsible for the oxidization of sulfur to sulfite which is converted into sulfate by the sulfoxidation process. This dysfunctional liver pathway could be related to this viscous cycle in acquiring CFS/ME.
Stomach acid plays a big part in breaking down the food we eat. Hydrochloric acid and bile acids are needed to maintain a proper balance of gut flora, as well as liberate key nutrients such as B-12. We have identified that these insufficiencies can lead to developing dysbiosis in the small intestine, leading to malabsorption and leaky gut. Intestinal permeability can open the door to autoimmune conditions and immune system dysfunction. There are many factors that can cause a Hydrochloric acid / Bile acid deficiencies.
See more here http://forums.phoenixrising.me/index.php?threads/how-i-recovered-from-cfs-part-2.28684/
Intestinal bacterial overgrowth (SIBO) can be the underlying cause for many of the symptoms associated with fibromyalgia and chronic fatigue syndrome.These bacteria can be aerobic as well as anaerobic. SIBO can lead to a overproduction of toxins such as D-lactic acide, Hydrogen sulfide, Acetaldehyde, Endotoxins. These toxins can impair the brain causing fatigue and mitochondrial damage. Bacterial cellular debris can stimulate the production of endogenous interleukin-1 and tumor necrosis factor. LPS can cause inflammation and mitochondrial impairment. Bacteria and yeast overgrowth can also produce hydrogen sulfide (H2S) that can bind to the mitochondrial enzyme cytochrome c oxidase, part of the electron transport chain. This can also impair oxidative phosphorylation and ATP production. Hydrogen sulfide is a neurotoxin and metabolic poison and can cause fatigue, muscle pain and dyscognition. These bacteria imbalances can produce tryptophanase which can digests tryptophan that is the main building block for serotonin and ultimately melatonin. Tryptophan depletion leads to melatonin deficiency which in turn leads to sleep disturbances, mitochondrial impairment and oxidative stress as well as muscle fatigue. Finally these bacterial overgrowths can also produces D-lactic acid which is a neurotoxin as well as a metabolic poison in abnormal amounts.
There are many contributing factors that can overwhelm the body's metabolism such ; lyme disease, viruses, non-cytolytic viruses, mold, toxic exposure as well as dysbiosis, endotoxins and even physical exertion can all dramatically affect the liver's detoxification process. Chronic viral infections and mercury toxicity have been associated with chronic inflammation of the liver and kidneys, further inhibiting
PST enzyme as well as sulfate recycling. The sulfate transporters in the kidneys can be blocked by mercury which build up because of glutathione depletion. Sulfate has several important jobs that including sulfating DHEA and toxins including phenols from certain foods. There is also the NaSi-1 gene that can be inhibited by mercury and contribute to the faulty sulphate transporter proteins. Sulfate-reducing bacteria in the gut can also be a problem as it is needed to convert sulfate to hydrogen sulfide, which is toxic at high enough levels. Sulfate is also required for mucus production need for many protective functions in the body. Bacteria and yeast overgrowth can also produce hydrogen sulfide (H2S) that can bind to the mitochondrial enzyme cytochrome c oxidase, part of the electron transport chain in the krebs cycle. This can also impair oxidative phosphorylation and ATP production. When mitochondria become damaged due to a buildup of toxins, energy production is greatly impaired. Ultimately the mitochondria pays the price for the livers weak detoxification ability.
Renal Na-Si cotransporter NaSi-1 is inhibited by heavy metals.
http://www.ncbi.nlm.nih.gov/pubmed/9486223
The main focus is to prevent
Apoptosis (cell death) and it's imperative that we start mitochondria supportive therapy and identify and treat gut, liver imbalances as well as intracellular deficiencies before the mitochondrial damage progresses to the point of no return. We need to treat the root cause and not the symptoms of disease. Supportive care needs to be considered at some point to maintain the best quality of life for those with long term irreversible mitochondria damage.
Sulphation diagram: http://www.allnaturaladvantage.com.au/Sulphation_diagram.htm
Salicylate Sensitivity http://salicylatesensitivity.com/forum/comments.php?DiscussionID=1401
Phenols/Salicylates http://healingautismandadhd.wordpress.com/diet-2/phenolssalicylates/
See more here: http://www.newtreatments.org/fromweb/sulfur.html