Hi all, I did the 23andme thing and recently received my results. I would appreciate any feedback as to whether or not I am going about this the right way. +/+ for MTHFR A1298C MAO-A R297R MTRR A66G MTRR A664A SHMT1 C1420T +/- for COMT V158M COMT H62H VDR Bsm VDR Taq BHMT-02 BHMT-04 BHMT-08 CBS A360A Due to my COMT +/-, I have only used 500mcg HB12 every other day for a few weeks to address the MTRR. Any more than that I start getting a sore throat, headache and tooth pain. I plan on titrating up when I can tolerate it. Methylfolate so far has made me irritable at 1000mcg doses. I have no other dose options available at the moment so I have quit taking it for the time being. I'm not so sure I need it anyway with the A1298 mutation. Homocysteine levels have been 6-7 for the last year. Started 100mg PS for the BHMT 500mg L Carnitine and 200mg CoQ10 for energy and CBS For the CBS: I will test for ammonia levels and sulfate levels to confirm or rule out its involvement in my poor health. I have already started to take out sulfur foods from the diet to help if need be. I do eat a great deal of protein, 1g/lb of BW (200g), but will not lower that much if any until blood work is done for ammonia levels. I have activated charcoal on hand to take if need be and take magnesium everynight anyway. Any more tips? Criticism? Have I at least go a decent start? Thanks!!