Viral infections are repeatedly seen to be a factor in PRS; many cases are thought to begin with a viral infection. There have been other theories regarding the etiology of PRS, for instance, the
psychodynamic theory of fatal mothering and a potential neurobiological role of the
insula.
[7] Von Folsach and Montgomery put forth four essential etiologic factors: (1) a premorbid personality, (2) a history of child psychiatric problems, (3) parental psychiatric problems and (4) sudden stressful events.
[7] PRS children are typically known to be
perfectionists, conscientious and high achievers. When these children are put in stressful events that they feel they cannot control, they go into a state of
learned helplessness. Previous child psychiatric problems can designate a susceptibility to develop PRS when put in stressful situations, and parental psychiatric problems may influence the parents’ capability to support and care for their children.
[7]