According to the information from Walsh's book, I would say you are overmethylated. How does niacinamide make you feel?I have been trying (three weeks in) pacing my activity according to the 20 mn activity/15 mn rest pattern. For the time beeing, I can't draw conclusions becquse so many things interracted (reaction to meds). But I am still into this and intend to apply this as much as I can.
How do I know I am under methylating or not ?
I take only little supplement with methyl groups (don't tolerate SamE) like methylB12 (1 mg/day) because otherwise I am wired and feel anxiety. Am allergic to most of the antihystamin stuff, have plenty of other food intolerances (gluten-diary-sulfite etc) and MCS, but no real seasonal allergies.
It does sound like you might be undermethylated. I am revising the NAD part of my hypothesis because I am beginning to think that the NAD problem isn't because of not having enough niacinamide, but with having an increased need for de novo purine synthesis. Niacinamide helps overmethylated people for a reason not related to NAD synthesis.As I have said a few times already, whenever I increase B3 or reduce folate, I run into problems. I do have seasonal allergies. So perhaps I am generally undermethylated.
Almost universally it seems that PWMEs do not tolerate B3 very well, and generally do well with folate, and this is one thing that makes me a bit skeptical about @Kimsie's NAD hypothesis.