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In vitro it is clearly demonstrating infectivity and in explants and a variety of human cell lines and it can transmit into non-human primates. I'm a little concerned, this was human created in the laboratory and its a highly infectious retrovirus. And subsequent to that event, could it transmit to humans? We've been doing studies in pedigreed negative controls, some of whom happen to be lab workers working with this virus who intermittently score positive in one lab or another and I've just ignored that but now I'm beginning to be a little concerned that might there be transient infections in humans.
currer. Rhetorical? Doesn't of course rule out vaccinations or human to human transmission. And as you eliminate some routes, you make others more likely.Looks like the vector cannot be lab workers...what does that leave...?
Why is Dusty Miller being so disingenuous in his statement about xenotransplantation?
The concerns expressed in the paper are not dismissed by this equivocation.
The Zhang paper clearly states in the discussion section
"However three of the nine positive samples contained varying amounts of mouse DNA, presumably as a result of survival of mouse stromal cells from the mouse xenograft. Apparrently, the mouse stromal cells may persist for lengthy periods in culture, occasionally in excess of one year."
Does Dr Miller believe we cannot read research papers in the public domain on the internet?
Edit. Stromal cells are connective tissue cells from the mouse which would have formed as the human cancer xenograft transplant healed and grafted successfully onto mouse tissue.
Edit. "a little learning is a dangerous thing" Pope.
A frequently used quote from the eighteenth century in England used tio justify denying education to the labouring classes. - often in conjunction with the argument that wages should be kept at starvation level or the feckless labourer would not work.
Silverblade, where are you?