Cucurmin for chronic fatigue syndrome (ME/CFS)Cucurmin is..

derived from tumeric, a staple of Indian cusine and Aryuvedic medicine for thousands of years. Known for its aromatic, stimulant and carminative properties tumeric has been used in traditional Chinese medicine to treat liver and gallbladder problems and stimulate digestion. Some physicians have recently begun to use curcumin to treat chronic fatigue syndrome (ME/CFS) as well.

The biologically active phytochemical present in tumeric, curcumin was first isolated in 1910. Animal studies suggest it has anti-inflammatory, anti-viral, anti-tumor, antioxidant and anti-ischemic properties – all of which may be of concern in CFS. Cucurmins ability to reduce neuroinflammation and oxidative stress in the brain may be of particular interest to ME/CFS patients.

Studies suggest curcumin may be able to assist with exercise, learning, overstimulation and depression. Cucurmin’s anti-inflammatory properties have been used to reduce the swelling and arthritis and ease muscle pains from exercise. Studies suggest it may be helpful in many inflammatory conditions including diabetes, arthritis, aetherosclerosis and inflammatory bowel as well as fibromyalgia and peripheral neuropathy.

Curcumin may have similar effects as anti-Tumor Necrosis Factor (TNF) drugs, some of which are being explored in special subsets of CFS patients and as anti-NF-kB drugs. Some researchers believe that NF-kB, a transcription factor that promotes inflammatory conditions, is overactive in chronic fatigue syndrome (ME/CFS). Cucurmin also appears to have positive effects on amyloid production in rodent studies on Alzheimer’s – an intriguing finding given that one study suggests amyloid deposition may be occurring in the ME/CFS patients as well. Curcumin is also a potent nitric oxide free radical scavenger and can reduce F2 isoprostane levels – which studies indicate are high in CFS.

A Patent Court’s ruling that tumeric’s properties were not patentable may have blunted pharmaceutical companies interest but clinical trials are under way in a wide variety of diseases including several cancers, psoriasis and Alzheimer’s disease. Interestingly, a recent study found that cucurmin was more effective than a refined metabolite of cucurmin called Tetrohydrocurcumin. The study established that curcumin supplementation is the most effective means of receiving this treatments benefits.

Some studies have questioned whether cucurmin absorption is sufficient for its effects to take place. A 2006 study found that even ‘high dosing levels’ did not result in detectable levels of curcumin in the plasma. A 2008 study suggested, however, that supplementing curcurmin with olive oil, phosphatidyl choline or stearic acid increases curcurmin plasma levels 11-fold and brain levels 4-fold. Curcumin absorption may be increased when it is not taken with other food. The studies authors suggested that traditional Indian culinary practices of dissolving tumeric in fat while cooking could contribute to reduced levels of Alzheimers in India.

Cucurmin Might Be Helpful In Chronic Fatigue Syndrome (ME/CFS) Because….

 it’s anti-inflammatory and anti-oxidant properties may help combat the inflammation present

Chronic Fatigue Syndrome (ME/CFS) Studies


Chronic Fatigue Syndrome (ME/CFS) Doctor’s Report

Recommended Dose

 500-1,000 mgs/day – can be increased due to low incidence of side effects


A Golden Gift of Nature


GcMAF Australia August 19, 2012 at 12:59 am

Curcumin binds to the vitamin D nuclear receptor (VDR) and also the retinoid X receptor. So its effects could be related to the actions of vitamin D. Both curcumin and vitamin D stimulate
amyloid-beta clearance by macrophages of Alzheimer’s disease patients. Combination of the two gives additive effects.
This may assist amyloid removal of toxins from the brain.

Woolie December 1, 2014 at 10:23 pm

I’ve recently been experimenting with curcumin, various brands, including Jarrow curcumin with phytosome and pure curcumin extract in powdered form. Following recommendations here and in the literature, I took it in generous amounts: 400mg per day to 1g. After trying it off an on for several days one week apart, I’ve been able to establish clearly that it gives me severe diarrhea. I’m mentioning this because it took me ages to make the link, and there were no other reports on the forums of this reaction. So it was the last thing I was expecting.
I normally tolerate all foods and medications fine.
Give it a go, but if you find you have a stomach upset around that time, take care cos it just might be the curcumin!

Jacqueline Christensen July 12, 2015 at 5:37 am

I have been taking Turmeric now for approximately six months. I now take 3g in a cup of coconut or rice milk. I add pepper, and bring the mixture to the boil, to make it more bioavailable.
Over the months I have gone from feeling like the ‘living dead’ and wondering if I shouldn’t pull the plug – I’m 75, and was diagnosed in 1990 – to feeling alive. Post Exercise Malaise has always been my worst, and most disabling symptom. Often, I’ve been so ill that I’ve felt I was dying.
Now, I am lifting 2 kg weights and, some days, walking about half a kilometre. If I continue to improve at this rate, perhaps in another year I may be able to say that I no longer have M.E.
The turmeric has also lowered my blood pressure, which was dangerously high.

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