Several immune abnormalities – most notably natural killer cell dysfunction – have been identified in ME/CFS patients since the first person came down with a wrenching cold they never recovered from in the Incline Village outbreak  over 25 years ago.

Several doctors regularly use antiviral and immunomodulatory drugs or supplements in their practices. Anecdotal reports of Ampligen’s effectiveness abound and interest in immunomodulatory drugs has increased since the Rituximab findings and as researchers and doctors have been better able to pinpoint abnormalities in the immune system. Few studies, however, have been done.






{ 4 comments… read them below or add one }

Enid May 14, 2013 at 5:33 am

What a marvellous and concise article, pinpointing the essential – being Immune abnormalities. It’s been a long twelve years for me and those in the UK awaiting medicine to catch up here.


Lorraine December 11, 2013 at 6:55 pm

Great to find this site after struggling 15yrs with CFS and now Leukopenia which I realise now is connected to the two auto immune conditions i have (coeliac and Fibromyalgia) Thankyou !


monica December 13, 2013 at 4:00 am

Very good article. I sometimes use this page to explain to people what the potential meds are for people with M.E. Hope that’s o.k. with you?
Here in The Netherlands research is very much behind (no serious research), but I am trying to change that. Thank you for the information!!
There is not so much unclear about M.E./cfs. Can’t we combine the research that has been done and just declare:

M.E. is a neurological immune disease caused by one or several (viral) infections.

A clear statement will help us not having to explain ourselves, and being taken more seriously! What can we add to this definition?

greetings Monica


Todd Larson March 4, 2015 at 2:53 am

I have been living with CFIDS for at least 27 years now. I am 52. Because of multiple cases of pneumonia and my low IGG and it’s subclasses, my doctors started giving me injections(and occasional IV) immunoglobulins. I have been on this therapy, weekly, for 7+ years now. My doctor would give me a pneumococcal vaccine and check my immune response, before and after, for antibodies. The lack of antibodies confirmed my condition and the need for the treatments. I believe those shots/IV have saved my life several times now. I am grateful to be alive!
Todd in South Florida


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