Dexedrine is..

an amphetamine. Dexedrine is often prescribed for daytime sleepiness (narcolepsy), attention deficit disorder and depression. Amphetamines such as Dexedrine increase alertness, energy and motivation and at times sexual drive. Dexedrine is believed to increase the concentrations of dopamine, in particular, and norepinephrine and serotonin to some extent.

Dexedrine May Work in Chronic Fatigue Syndrome (ME/CFS) Because

it is prescribed for three conditions; daytime sleepiness, poor concentration and depression that are often found in ME/CFS. Dexedrine may increase the concentrations of some neurotransmitters that may be low in ME/CFS.

Chronic Fatigue Syndrome (ME/CFS) Studies

One small study found improved fatigue levels after dexamphetamine treatment.

Chronic Fatigue Syndrome (ME/CFS) Physicians Report

 Dr. Teitelbaum states Dexedrine can helpful by increasing blood pressure (and standing), decreasing the weight gain often seen (leading to better sleep and less pain) and increasing energy. He has found it to be ‘very safe and effective’ with the proviso that the rest of the body is supported by a comprehensive treatment program. He believes Dexedrine is underused in ME/CFS. A recent paper in the Medical Hypotheses journal by Dr. Check proposes Dexedrine is an effective tool for fighting chronic fatigue syndrome (ME/CFS) and other disorders.


Dr. Rowe suggests ME/CFS patients using Dexedrine for orthostatic intolerance begin with 5m spansules in morning. If no improvement is seen increase to 2 or 3 spansules in the morning.

Possible Side Effects

Overstimulation, sleeplessness, rapid heart rate, tremor, potential drug dependence, tolerance, multiple drug interactions and more. All amphetamines can be addictive if abused.


This summary was put together by a layman with ME/CFS and is not intended to provide complete information on the side effects or any other aspects of this drug. It is for informational purposes only.


Check, J.H., Katsoff, D., Kaplan, H., Liss, J., Boimel. 2007. A disorder of sympathomimetic amines leading to increased vascular permeability may be the etiologic factor in various treatment refractory health problems in women. Medical Hypotheses. Article in press.

Olson LG, Ambrogetti A, Sutherland DC. 2003. A pilot randomized controlled trial of dexamphetamine in patients with chronic fatigue syndrome. Psychosomatics Jan-Feb;44(1):38-43.

Jacob Teitelbaum, 2007. From Fatigued to Fantastic 3rd ed., Avery Press.

Wikipedia: Dexedrine

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