a prescription drug produced from pig liver that is believed to have anti-inflammatory and anti-viral properties. Favorable responses to NEXAVIR® in patients with skin diseases (acne vulgaris, herpes zoster, “poison ivy” dermatitis, pityriasis rosea, seborrheic dermatitis, urticaria and eczema) and severe sunburn have been reported. 1994 and a 1996 studies suggested Nexavir may be able to block HHV-6 and Epstein-Barr Virus activity in test tubes.
Nexavir, formerly kutapressin, is available from www.nexcopharma.com/. The PubMed data base lists two Nexavir studies in the last forty years.
Nexavir May Work in Chronic Fatigue Syndrome (ME/CFS) Because..
it has anti-inflammatory effects and it may inhibit two viruses HHV-6 and EBV that may be reactivated in some patients.
Chronic Fatigue Syndrome (ME/CFS) Studies
No studies have examined this drug’s effectiveness in ME/CFS.
Chronic Fatigue Syndrome (ME/CFS) Doctor’s Report
Two Houston doctors reported, in non-peer reviewed, in-practice 1990 study that 75% of 270 patients improved significantly. A second non-peer reviewed, non-placebo controlled study by the same doctors reported that 41% of patients achieved remission.
Dr. DeMeirleir uses Nexavir in combination with injections of Vit. B-12 (10 mg./twice weekly) to reduce pain and improve sleep. From 60-70% of his and Dr. Enlander’s patients reportedly responded positively to the drug. Dr. De Meirleir reported that 70% of his patients respond quite well (20+ points increase in Karnovsky scale) to Nexavir.
Dr. Cheney used Nexavir as an immunomodulator and broad spectrum antiviral and has called it a ‘weaker form of Ampligen’. According to the CFSSufferer blog Dr. Cheney reports that Nexavir in combination with other treatments results in a 20-80% improvement. Dr. Cheney stopped using Nexavir after his ‘echo-terrain’ maps suggested to him that the drug may have negative effects.
Dr. Teitelbaum has seen ‘dramatic improvement’ with regular use of the drug but notes that regular treatment can be difficult given its expense. He also notes that symptoms may return after the drug is discontinued. Dr. Lapp calls it a ‘wonderful alternative’ with the proviso that its expensive and the shots can be painful.
Dr. Enlander uses an alternative to Kutapressin called Hepapressin. He reports that when used with other treatments weekly Hepapressin injections 2/3rds of his patients improve.
Cost is reportedly approximately $500/month and 6 months may be needed to assess the effectiveness of the drug.
Dr. Cheney reported Nexavir is most effective when the dose is varied or pulsed. He recommends that the dose be varied from 1 to 4 cc daily. The injections, reportedly, can be painful. Nexavir can be applied as a gel.
The Phoenix Rising website is compiled by a layman. It is not a substitute for a physician and is for informational uses only. It does not present complete information on this drug. Please discuss any treatments in these pages with your physician.
- Dr. Cheney on Rebalancing the Immune System in Chronic Fatigue Syndrome:. 2001. Transcript of a patients appointment by Carol Sieverling.
- Dr. Charles Lapp: The Treatment of Chronic Fatigue Syndrome. Prohealth.com
- Nexavir (Kutapressin) for CFS
- Jacob Teitelbaum, M.D. From Fatigued to Fantastic, 2007
- Symposium on Viruses in Chronic Fatigue Syndrome (ME/CFS) Part II_