Glutathione and the Methylation Cycle by Rich Van Konynenburg Ph.D.
Rich Van Konynenburg, Ph.D., an independent researcher, believed that glutathione depletion causes many of the problems in ME/CFS. The master anti-oxidant in the body, glutathione also plays a role in amino acid transport, protein synthesis, the cell cycle and immune cell proliferation.
These papers by Rich Van Konynenburg examine ways to enhance glutathione, detoxification and energy production in ME/CFS.
Rich died unexpectedly in his sleep on Sept 25th, 2012.
- A Simplified Treatment Approach Based on the Glutathione Depletion-Methylation Cycle Block Pathogenesis Hypothesis for Chronic Fatigue Syndrome, Part I: Theory and history
- Simplified Treatment Approach Based on the Glutathione Depletion- Methylation Cycle Block Pathogenesis Hypothesis for Chronic Fatigue Syndrome, Part II: the Treatment Plan
- Interpretation of the Methylation Pathways Panel
- Augmenting Glutathione in Chronic Fatigue Syndrome - The most extensive resource on the net of the many different ways used to boost the levels of this master antioxidant in the body. This was superseded by Rich’s Methylation Cycle Treatment Plan.
Videos of Rich’s 2001 talk in Sweden
- Is Glutathione Depletion an Important Part of the Pathogenesis of Chronic Fatigue Syndrome? (2004) - Rich’s original paper in which he describes why he believed glutathione depletion plays a central role in ME/CFS; largely superseded by the Methylation Blockade Theory paper below.
- Glutathione Depletion-Methylation Cycle Block: A Hypothesis For the Pathogenesis of Chronic Fatigue Syndrome - A paper presented at the 2007 IACFS/ME Conference.
- Methylation Cycle Blockade Theory - How the hypothesis came about, what it is, why the Yasko-Autism connection fits, and why he believed it pertains to ME/CFS (7/07).
- A Simpler Explanation of the Glutathione/Methylation Blockade Theory (12/08) - Rich provided a step-by-step, simpler explanation of his theory.
- Chronic Fatigue Syndrome and Autism - exploring possible connections between CFS and autism.
- Methylation PPP- Download Rich’s powerpoint presentation to the 2008 Orthomolecular Health Medicine Society on Glutathione, Methylation and chronic fatigue syndrome.
- Why is the Prevalence of CFS Higher in Women Than in Men? (2007)