Glutathione and the Methylation Cycle by Rich Van Konynenburg Ph.D.

Rich Van Konynenburg proposed that methylation blockades played a key role in chronic fatigue syndrome and autism and created a popular treatment protocol for ME/CFS

Rich Van Konynenburg, Ph.D., an independent researcher, believed that glutathione depletion causes many of the problems in ME/CFS.  The master anti-oxidant in the body, glutathione also plays a  role in amino acid transport, protein synthesis, the cell cycle and immune cell proliferation.

These papers by Rich Van Konynenburg examine ways to enhance glutathione, detoxification and energy production in ME/CFS.

Rich died unexpectedly in his sleep on Sept 25th, 2012.

Treatment papers

Videos of Rich’s 2001 talk in Sweden

Theory papers

George @ the High Fat hep C Diet November 27, 2012 at 3:40 pm

I’m very sorry to hear that Rich is dead. I corresponded with him extensively some years ago and his ideas on methylation and glutathione helped build my own understanding of Hepatitis C, where hypomethylation is a factor in liver degeneration and predicts a poor response to drugs. (HCV is of course one possible cause of CFS/ME, and the presence of the virus shouldn’t preclude a dual diagnosis).
Rich was very helpful and generous to someone struggling to understand.

caledonia March 6, 2013 at 1:17 pm

This is a great summary of Rich’s work; I refer to it often. By the way, Rich’s last name is spelled wrong in the title – it says Von instead of Van.

caledonia March 6, 2013 at 1:20 pm

Also, the title “Video’s” should not have an apostrophe. It should simply be “Videos”. Yes, the spelling and grammar police are out in full force today. lol

Bluebell July 2, 2013 at 2:55 pm
Virginia Waters October 2, 2013 at 2:44 pm

My son and I are just starting on the correct forms of b vitamins for the heterozygous c667t mthfr mutaion. We started at a low dose two weeks ago and are already having a positive effect. We are under the care of an expert doctor for guidence on the correct protocol for us. I will post here in a few months for an update.

Eva Blackwell October 5, 2013 at 3:33 pm

Hi Virginia,
My son and I are just starting the MTHFR investigation. If I may ask, which test did you use to get your information? I just ordered the 23andMe for both of us. My son is 15 y.o. and is homebound due to CFS. We have been looking for help for him for about 2 years and have not got any answers yet. I am sick with CSF and Fibromyalgia and have been sick most of my life. We are hopeful that there my be a genetic mutation that will help treat us both. Very interested in you experience!

Thank you,
Eva Blackwell

Beverly Zeroogian March 4, 2014 at 5:44 am

Hi Eva- I have a 15 year old son in a similar situation. He has a vestibular trauma 2.5 years ago and it affected his autonomic nervous system. I’d like to know more about what you are doing. There is so little support for parents of children in situations like this. Please email me-

Nancy June 15, 2014 at 8:50 am

Could u tell me what kind u use. Have been sick for over 20 yrs. I can’t do research any more but can follow directions. Thanku so much

jennifer March 5, 2014 at 6:32 am

chelation therapy google dr carey winnerstorm or carey johnson kansas city mo

Clifton June 29, 2014 at 9:53 am

I am following the Methylation cycle protocol. I started the Actifolate at 200 mcg for 7 days, then I increased the dosage to 400 mcg. But the second day at 400 mcg I felt terribly ill so I went back to 200 mcg for 4 days. Each time I increase to 400 mcg folate I feel terrible on the second day.
What is the best way to handle the increased dosage of folate ? Is there an ideal way to take the folate to avoid these terrible side effects ?


Jared July 23, 2014 at 2:28 pm

You may be taking too much, each person is individual with how much folate and other b vitamins they can take. It may be due to inflammation but it could also be due to overmethylation if your having side effects, does it happen if you trry 300 mcg?

Brock April 7, 2015 at 10:41 pm

thanks for sharing this information. if anyone is curious to know about another way (scientifically proven) to increase glutathione levels please let me know and i would be happy to share :) so grateful we have other options

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