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Rich Van Konynenburg, Ph.d.

Treating Chronic Fatigue Syndrome (ME/CFS): Glutathione and the Methylation Cycle

Rich Van Konynenburg, Ph.d., an independent researcher, believes glutathione depletion causes many of the problems in ME/CFS. Glutathione is the master anti-oxidant in the body.  Besides being involved in scavenging free radicals and degrading a wide variety of toxins glutathione plays a role in amino acid transport, protein synthesis, the cell cycle and immune cell proliferation.

These papers by Rich Van Konynenburg examine ways to enhance glutathione, detoxification and energy production in ME/CFS. (For the underpinnings of Rich’s theory see the Research Section)



  • Augmenting Glutathione Levels in CFS – The most extensive resource on the net of the many different ways used to boost the levels of this master antioxidant in the body. This has been superseded by Rich’s Methylation Cycle Treatment Plan – see below.
  • Treating Glutathione Depletion-Methylation Blockades in CFS – A ‘Simple Guide’ to enhancing the glutathione/methylation cycles from Rich Van Konynenburg (Jan 2007) – Rich updated this in July- see below.
  • Methylation Cycle Blockade Treatment Plan – A July 2007 update to Rich Von Konynenburg’s Glutathione/Methylation Treatment Plan
  • New! The Methylation Treatment Study – presented at the IACFS/ME Conference in Reno in March, 2009. In partnership with Neil Nathan, MD., Rich Van Konynenburg presents the results of the first treatment trial of the Methylation Treatment plan.

Sign the petition to get ME/CFS a research budget of $250 million a year!
There's a US petition and a global solidarity petition here with a long-term target of 50,000 signatures. Time we were on an equal per-patient funding basis with similar diseases!