Rich Van Konynenburg, Ph.d.

Treating Chronic Fatigue Syndrome (ME/CFS): Glutathione and the Methylation Cycle

Rich Van Konynenburg, Ph.d., an independent researcher, believes glutathione depletion causes many of the problems in ME/CFS. Glutathione is the master anti-oxidant in the body.  Besides being involved in scavenging free radicals and degrading a wide variety of toxins glutathione plays a role in amino acid transport, protein synthesis, the cell cycle and immune cell proliferation.

These papers by Rich Van Konynenburg examine ways to enhance glutathione, detoxification and energy production in ME/CFS. (For the underpinnings of Rich’s theory see the Research Section)



  • Augmenting Glutathione Levels in CFS – The most extensive resource on the net of the many different ways used to boost the levels of this master antioxidant in the body. This has been superseded by Rich’s Methylation Cycle Treatment Plan – see below.
  • Treating Glutathione Depletion-Methylation Blockades in CFS – A ‘Simple Guide’ to enhancing the glutathione/methylation cycles from Rich Van Konynenburg (Jan 2007) – Rich updated this in July- see below.
  • Methylation Cycle Blockade Treatment Plan – A July 2007 update to Rich Von Konynenburg’s Glutathione/Methylation Treatment Plan
  • New! The Methylation Treatment Study – presented at the IACFS/ME Conference in Reno in March, 2009. In partnership with Neil Nathan, MD., Rich Van Konynenburg presents the results of the first treatment trial of the Methylation Treatment plan.
Dr. Tim Jackson, DPT October 2, 2012 at 5:34 pm

This is a message for Dr. Rich’s wife. I wanted to offer my sincere apologizes for your loss. And to thank you for everything your husband did for our field of medicine. In addition, I wanted to offer my services in terms of helping on the forums if needed.

God Bless,

Tim Jackson

Karen Vrchota, M.D. November 23, 2012 at 5:10 pm

Rich Van K was an inspiration to all of us who have dedicated our lives to solving the mystery behind CFIDS. He combined intelligence, open-minded curiosity, and a willingness to look into many perspectives to develop an ever evolving perspective to this complex illness.
He helped many of my patients gain a working diagnosis and whittle down the number of contributing factors contributing to their particular situation. I know of at least 10 people who would not be alive today without his brilliant input.
And that is the tip of the iceberg. Many others would read his generous online postings and find help and inspiration.
We will miss his smile and questions and constant support.
Karen Vrchota, M.D.

Chris February 7, 2013 at 4:32 pm

I heard Doctor Rich Van died last year and feel sorry for the family and friends. He did remarkable work in field of DNA methylation but please also tell the real cause of his sudden death?
He was so up to date in all tests and everything and now we all loss the support which we used to get from him. He was helping so many by giving advise and right info.

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